For treating a leading cause of osteoporosis, surgery is better than widely used medications

While most cases of osteoporosis are caused by normal aging, another leading cause of the bone-loss disease is a condition called hyperparathyroidism, in which the parathyroid glands release an excessive amount of a hormone that regulates the body’s calcium levels. Doctors commonly treat hyperparathyroidism using a class of prescription drugs called bisphosphonates, including alendronate (marketed under the brand name Fosamax) and ibandronate (Boniva), which are supposed to strengthen bones. Now, a study led by scientists at UCLA found that those drugs actually increase the risk of fracture, meaning that taking them is worse than doing nothing at all to treat the condition. The research also revealed that patients who have surgery to remove the overactive parathyroid glands have fewer subsequent bone fractures. The report appears in the April 5 issue of the Annals of Internal Medicine. About 400,000 people in the U.S. — 1 in 400 women and 1 in 1,200 men — have hyperparathyroidism; and osteoporotic fractures are a major public health and economic burden, said Dr. Michael Yeh, an associate professor of surgery and medicine, and the study’s first author. “Hip fractures in particular are associated with significant rates of mortality, disability and loss of independence,” said Yeh, who also is the chief of endocrine surgery at the UCLA David Geffen School of Medicine. “Before this study, there was no data that compared parathyroid surgery...
Source: UCLA Newsroom: Health Sciences - Category: Universities & Medical Training Source Type: news

Related Links:

Authors: Ding L, Xiao L, Lin X, Xiong C, Lin L, Chen S Abstract Background: Few studies focused on the region of interest- (ROI-) related heterogeneity of liver intravoxel incoherent motion (IVIM) diffusion-weighted imaging (DWI). The aim of the study was to evaluate the differences of liver IVIM parameters among liver segments in cirrhotic livers (chronic viral hepatitis). Material and Methods: This was a retrospective study of 82 consecutive patients with chronic liver disease who underwent MRI examination at the Jinan Infectious Diseases Hospital between January 2015 and December 2016. IVIM DWI (seven differ...
Source: Gastroenterology Research and Practice - Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research
ConclusionsThe optical tracking system seems clinically acceptable for precise tracking of the maxillary position during navigational orthognathic surgery notwithstanding the chance of greater measurement error on the y-axis.
Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology - Category: ENT & OMF Source Type: research
ConclusionComputer-aided planning and the use surgical guides in accordance with CBCT images may help inexperienced clinicians to place implants with a high accuracy.
Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology - Category: ENT & OMF Source Type: research
Authors: Y D, Manjrekar PA, Adhikari P, M C, Ms R Abstract Vitamin D, a steroid hormone is primarily known for its role in calcium and bone mineral homeostasis. Over the years, vitamin D has been implicated in various non-skeletal diseases. The extraskeletal phenomenon can be attributed to the presence of vitamin D receptors (VDRs) in almost all cells and identification of 1-α hydroxylase in extrarenal tissues. The vitamin D deficiency (VDD) pandemic was globally reported with increasing evidence and paralleled the prevalence of diabetes, obesity and cardiovascular diseases (CVDs). A dependent link was propos...
Source: Cardiovascular and Hematological Disorders Drug Targets - Category: Drugs & Pharmacology Tags: Cardiovasc Hematol Disord Drug Targets Source Type: research
A 73-year-old female presenting with haemoptysis and dyspnoea was found to have a locally advanced left thyroid mass and vocal cord palsy. A CT scan of the neck and thorax and endoscopy demonstrated invasion into the tracheal lumen. Histopathology of the intraluminal tracheal mass confirmed a papillary thyroid cancer (PTC). The tumour was deemed unresectable due to local extent and patient comorbidities. TKI therapy with lenvatinib was used for 14 months. On serial scanning, a marked reduction in tumour volume from 31 × 59 × 32 mm to 17 × 28 × 22 mm was noted. This subsequently allowed a successful ...
Source: European Thyroid Journal - Category: Endocrinology Source Type: research
ConclusionThere is a decrease in BMR in women with T2DM with postmenopausal osteoporosis. BMR was significantly correlated with level of physical activity and visceral fat.
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - Category: Endocrinology Source Type: research
In this study, thermal analysis of 25 counterfeit Viagra and Cialis tablets seized by Brazilian Federal Police were performed by DSC and compared to their authentic medicines and analytical standards, along with chemometric tools. Authentic samples of Viagra displayed a similar thermal profile with the API, while Cialis were different with additional endothermic peaks, that could be related to excipients interference. Thermograms of Viagra counterfeit samples were similar to authentic samples, while Cialis showed an enlargement and displacement of endothermic peaks. Also, some Cialis counterfeit samples showed melting peak...
Source: Journal of Pharmaceutical and Biomedical Analysis - Category: Drugs & Pharmacology Source Type: research
Publication date: 20 March 2019Source: Journal of Pharmaceutical and Biomedical Analysis, Volume 166Author(s): Philippe J. Eugster, Haithem Chtioui, Adeline Herren, Marielle Dunand, Delphine Cappelle, Julien Bourquin, Thierry Buclin, Eric GrouzmannAbstractTeriparatide (PTH 1-34, Forsteo®) is a bioactive N-terminal fragment of the native endogenous parathyroid hormone (PTH 1-84) recommended for the treatment of osteoporosis in patients with high risk of fracture. Since PTH 1-34 may undergo proteolysis we have validated an ultra-high pressure liquid chromatography tandem mass spectrometry (UHPLC-MS/MS) method for unambig...
Source: Journal of Pharmaceutical and Biomedical Analysis - Category: Drugs & Pharmacology Source Type: research
Publication date: Available online 17 January 2019Source: PhytomedicineAuthor(s): Wagner B.R. Santos, Marlange A.O. Melo, Rafael S. Alves, Renan G. de Brito, Thallita K. Rabelo, Lindaura da S. Prado, Virginia K. dos S. Silva, Daniel P. Bezerra, José E.R. de Menezes-Filho, Diego S. Souza, Carla M.L. de Vasconcelos, Luciana Scotti, Marcus Tullius Scotti, Waldecy de Lucca Júnior, Lucindo J. Quintans-Júnior, Adriana G. GuimarãesAbstractBackgroundOncological pain is one of the most prevalent and difficult-to-treat symptoms in patients with cancer. p-cymene (PC) is a monoterpene found in more than 100...
Source: Phytomedicine - Category: Drugs & Pharmacology Source Type: research
ConclusionsThe microstructures, morphologies, and compositions of oxide films were influenced by the La content, and the La addition could significantly improve the metal-ceramic bond strength of dental casting Co-Cr alloys.
Source: The Journal of Prosthetic Dentistry - Category: Dentistry Source Type: research
More News: Boniva | Calcium | Disability | Funding | Health | Health Management | Hormones | Hyperparathyroidism | Internal Medicine | International Medicine & Public Health | National Institutes of Health (NIH) | Orthopaedics | Osteoporosis | PET Scan | Study | Universities & Medical Training | Vitamins | Women | X-Ray