For treating a leading cause of osteoporosis, surgery is better than widely used medications

While most cases of osteoporosis are caused by normal aging, another leading cause of the bone-loss disease is a condition called hyperparathyroidism, in which the parathyroid glands release an excessive amount of a hormone that regulates the body’s calcium levels. Doctors commonly treat hyperparathyroidism using a class of prescription drugs called bisphosphonates, including alendronate (marketed under the brand name Fosamax) and ibandronate (Boniva), which are supposed to strengthen bones. Now, a study led by scientists at UCLA found that those drugs actually increase the risk of fracture, meaning that taking them is worse than doing nothing at all to treat the condition. The research also revealed that patients who have surgery to remove the overactive parathyroid glands have fewer subsequent bone fractures. The report appears in the April 5 issue of the Annals of Internal Medicine. About 400,000 people in the U.S. — 1 in 400 women and 1 in 1,200 men — have hyperparathyroidism; and osteoporotic fractures are a major public health and economic burden, said Dr. Michael Yeh, an associate professor of surgery and medicine, and the study’s first author. “Hip fractures in particular are associated with significant rates of mortality, disability and loss of independence,” said Yeh, who also is the chief of endocrine surgery at the UCLA David Geffen School of Medicine. “Before this study, there was no data that compared parathyroid surgery...
Source: UCLA Newsroom: Health Sciences - Category: Universities & Medical Training Source Type: news

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The objective of this study was to evaluate the effect of a rehabilitation program in changing the perception of fatigue in patients with multiple sclerosis. MATERIAL AND METHODS The study involved 65 respondents/patients with clinically confirmed multiple sclerosis (54 women, 11 men, average age 46.49 years). The evaluation of the effects of fatigue on the physical, psychological, and psychosocial aspects of life was assessed using the Modified Fatigue Impact Scale (MFIS). To test the effectiveness of the neurorehabilitation program, we enrolled 2 groups: the experimental group (EG, n=32, 29 women, 3 men, Expanded Disabil...
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
Publication date: Available online 18 August 2018Source: British Journal of Oral and Maxillofacial SurgeryAuthor(s): Y. Yoshioka, E. Yamachika, M. Nakanishi, T. Ninomiya, K. Nakatsuji, Y. Kobayashi, T. Fujii, S. IidaAbstractCathepsin K inhibitors are new drugs with the potential for the treatment of osteoporosis because they sustain bony remodelling better than bone resorption inhibitors such as bisphosphonates. The treatment of osteoporosis with inhibitors of bony resorption is associated with osteonecrosis of the jaw, as the deterioration in bony quality that they induce is thought to be one of its causes. The quality of...
Source: British Journal of Oral and Maxillofacial Surgery - Category: ENT & OMF Source Type: research
Publication date: Available online 19 August 2018Source: Journal of Radiation Research and Applied SciencesAuthor(s): Nassreldeen A.A. ElsheikhAbstractMonte Carlo simulations were carried out to model a thermal neutron-induced gamma-ray sensor for anti-personnel-landmine (APM) or explosive detection. This is done by employing the thermal neutron prompt gamma activation (TNPGA) technique. The neutron capture reaction on nitrogen 14N(n,γ)15N is analyzed to detect the subsequent characteristic 10.8 MeV gamma rays. This is done by modelling a suitable geometry consisting of a point 252Cf source placed inside a sphere o...
Source: Journal of Radiation Research and Applied Sciences - Category: Physics Source Type: research
In conclusion, the solubility of NM and dissolution rate of NM-SD tablets were greatly improved by HME due to the recrystallization inhibition characteristic of HPMCAS-HF.Graphical abstract
Source: Colloids and Surfaces B: Biointerfaces - Category: Biochemistry Source Type: research
In this study, a novel magnetic adsorbent for Cr(VI) removal was synthesized by decorating corncob biochar with polypyrrole (PPy) (MBC/PPy). Scanning electron microscopy (SEM), fourier transform infrared spectra (FTIR), X-ray photoelectron spectroscopy (XPS) and vibrating sample magnetometer (VSM) were used to determine the removal mechanism of Cr(VI). The MBC/PPy composite had an outstanding Cr(VI) removal ability within a wide pH range (2.0–10.0). The adsorption process followed the pseudo-second-order kinetic and Langmuir isotherm models, and the maximum adsorption capacity was speculated as 19.23 mg/g at 2...
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After being told disease would destroy her vision, Paola Peretti wrote a children ’s novel – and found a template for lifePaola Peretti is losing her eyesight and she wouldn ’t have it any other way. When she was 14, she became very short-sighted, virtually overnight. Three years later came the diagnosis ofStargardt macular dystrophy, a degenerative disease that destroys central vision, damages colour perception and results in blindness. Two years ago, finding herself in a place of both “desperation and hope,” the 32-year-old Italian language teacher and debut novelist decided to step out from...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: Blindness and visual impairment Books Disability Health Culture Society Psychology Science Life and style & wellbeing Source Type: news
Abstract Positron emission tomography (PET)/computed tomography (CT) with 2-deoxy-2-[18F]fluoro-d-glucose (FDG) has become the standard of care for the initial staging and subsequent treatment response assessment for numerous gastrointestinal malignancies. However, it is often supplemented by magnetic resonance imaging (MRI) for local tumor staging. Hybrid PET/MRI scanners, which acquire PET data and MRI data simultaneously, have the potential to provide accurate whole-body staging in a single examination. Furthermore, to address certain limitations of FDG, many new PET tracers have been developed to probe distinc...
Source: Clinical Colorectal Cancer - Category: Cancer & Oncology Authors: Tags: Gastroenterol Clin North Am Source Type: research
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Source: Seizure - Category: Neurology Source Type: research
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Source: Journal of Ethnopharmacology - Category: Drugs & Pharmacology Source Type: research
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