News from ACC.16: ATMOSPHERE, Antiarrhythmics for Out-of-Hospital Cardiac Arrest, and More (FREE)

By the Editors For the past few days, NEJM Journal Watch has been bringing you breaking news from the American College of Cardiology's annual meeting in Chicago. Take a look at the latest: Aliskiren for Heart Failure: In the randomized ATMOSPHERE trial, adding the direct renin …
Source: Physician's First Watch current issue - Category: Primary Care Source Type: news

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Chronic Chagas disease cardiomyopathy (CCC) is the most frequent and severe form of this parasitic disease. CCC is caused by a progressive inflammation in the heart, resulting in alterations that can culminate in heart failure and death. The use of dendritic cells (DCs) appears as an option for the development of treatments due to their important role in regulating immune responses. Here, we investigated whether tolerogenic cells (tDCs) could interfere with the progression of CCC in an experimental model of Chagas disease. The tDCs were generated and characterized as CD11b+ CD11c+ cells, low expression of MHC-II, CD86, CD8...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Publication date: Available online 5 April 2020Source: Journal of Pharmacological SciencesAuthor(s): Wen-jing Li, Hai-han Liao, Hong Feng, Zi-ying Zhou, Shan-qi Mou, Nan Zhang, Hai-ming Wu, Hao Xia, Qi-zhu Tang
Source: Journal of Pharmacological Sciences - Category: Drugs & Pharmacology Source Type: research
AbstractSoluble urokinase-type plasminogen activator receptor (suPAR) is a membrane-binding protein that is released into the blood stream by immune activation. Recent reports suggest that circulating suPAR levels are associated with adverse cardiovascular outcomes. Exercise tolerance is an independent predictor of prognosis in patients with heart failure (HF); however, the relationship between serum suPAR level and exercise tolerance is unclear. We prospectively enrolled 94 patients who were hospitalized for worsening of HF. All patients underwent a symptom-limited cardiopulmonary exercise test to evaluate exercise tolera...
Source: Heart and Vessels - Category: Cardiology Source Type: research
This study evaluated 185 consecutive HF patients and underwent assessment including RFD, grip power (GP), knee extension strength (KES), skeletal muscle index (SMI), nutrition status, cardiopulmonary exercise testing, and New York Heart Association (NYHA) functional class. RFD was related with NYHA class and significantly correlated with GP, KES, SMI, body mass index, pre-albumin level, geriatric nutritional risk index, and peak VO2 (r = 0.631, 0.676, 0.510, 0.568, 0.380, 0.539, 0.527, respectively;p 
Source: Heart and Vessels - Category: Cardiology Source Type: research
AbstractThere are some similarities in clinical features between Takotsubo cardiomyopathy during the peripartum period (PTCM) and peripartum cardiomyopathy (PPCM). Both conditions present as acute heart failure and decreased left ventricular (LV) ejection fraction in the peripartum period in previously heart-healthy women. The present study aimed to evaluate the differences in clinical features and outcomes between PTCM and PPCM. Between January 2004 and December 2016, 37 consecutive patients who demonstrated LV dysfunction during the peripartum period without previous heart disease were recruited retrospectively. The clin...
Source: Heart and Vessels - Category: Cardiology Source Type: research
Condition:   Congestive Heart Failure Intervention:   Device: Atrial flow regulator (Occlutech® AFR device) Sponsor:   Szpitale Pomorskie Sp. z o. o. Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Volume Overload Interventions:   Dietary Supplement: Oral Sodium Chloride;   Other: Placebo Sponsor:   The Cleveland Clinic Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Heart Failure Intervention:   Other: Exercise Training Program Sponsors:   Centro Hospitalar do Porto;   Universidade do Porto;   Aveiro University Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Heart Failure Interventions:   Other: Improved primary care HF diagnostics;   Other: Heart Failure education;   Other: Structured transitional protocol planning post-discharge care Sponsor:   KU Leuven Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Three otherwise healthy patients go to the emergency department with severe acute respiratory failure. Only one ventilator, required to sustain life until the worst of the coronavirus infection has passed, is available. Who gets the vent? That’s what “A Framework for Rationing Ventilators and Critical Care Beds During the COVID-19 Pandemic,” a Viewpoint just published in the Journal of the American Medical Association (JAMA), addresses. Douglas White, MD, MAS, Endowed Chair for Ethics in Critical Care Medicine at the University of Pittsburgh School of Medicine ...
Source: blog.bioethics.net - Category: Medical Ethics Authors: Tags: Health Care Author: Lewis syndicated Source Type: blogs
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