Flutamide induces alterations in the cell-cell junction ultrastructure and reduces the expression of Cx43 at the blood-testis barrier with no disturbance in the rat seminiferous tubule morphology.

CONCLUSIONS: Short-term treatment with flutamide applied to adult rats exerts its primary effect on the basal ES, coexisting junctional complexes and their constituent proteins Cx43 and ZO-1, without any apparent morphological alterations in the seminiferous epithelium. In the interstitial compartment, however, short-term exposure leads to both histological and functional changes of the Leydig cells. PMID: 27036707 [PubMed - as supplied by publisher]

http://www.ncbi.nlm.nih.gov/pubmed/27036707?dopt=Abstract

Source: Reproductive Biology - April 4, 2016 Category: Reproduction Medicine Authors: Chojnacka K, Hejmej A, Zarzycka M, Tworzydlo W, Bilinski S, Pardyak L, Kaminska A, Bilinska B Tags: Reprod Biol Endocrinol Source Type: research