Need for streamlined use of DPP-4 inhibitors in the treatment of type 2 diabetes

Regulatory agencies request an assessment of cardiovascular safety for all “new” oral anti-diabetic drugs in order to avoid possible negative effects on cardiovascular events. Dipeptidyl peptidase 4 inhibitors...
Source: Cardiovascular Diabetology - Category: Cardiology Authors: Source Type: research

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Resumo Investigar os fatores associados ao controle glic êmico de pessoas com diabetes mellitus (DM). Estudo transversal realizado com 746 pessoas com DM tipo 2 e 40 anos ou mais de idade. Elegeu-se as seguintes variáveis: socioeconômicas, dados clínicos, estilo de vida e o risco para o desenvolvimento de úlceras nos pés. A coleta dos dados ocorreu por meio de entrevista, análise do prontuário e exame clínico dos membros inferiores. Utilizou-se o modelo de regressão múltipla de Poisson para determinação das razões de preval&ecir...
Source: Ciencia e Saude Coletiva - Category: Occupational Health Source Type: research
This study, titled “UK First NHS EndoBarrier Service for Advanced Type 2 Diabetes and Obesity: One-Year Outcomes in All Patients Treated,” is based on data collected from the first implant in October 2014 to the last explant in November 2018, a total patient population of 61. The primary outcome of HbA1c, weight, CVD risk factors and alanine aminotransferase (ALT — a liver fat measure) show a significant reduction at explant compared to baseline values. Of the 61 patients studied, 35 were on insulin prior to treatment. At explant, 10 of the 35 (28.6%) discontinued their...
Source: MDDI - Category: Medical Devices Authors: Tags: Business Source Type: news
SUMMARY Sodium-glucose cotransporter-2 inhibitors (SGLT2i) are drugs that act by maintaining glycosuria. Recent studies have shown promising effects of these in the treatment of type 2 diabetes mellitus (DM2). However, there may be an increased risk of developing urinary tract infections (UTIs) in patients treated with these. Our study aims to analyze the association between the risk of UTI in patients treated with SGLT2i. A systematic review of the literature was carried out by randomized clinical trials, totalizing at the end of the selection 23 articles that were statistically evaluated. The incidence of UTI was general...
Source: Revista da Associacao Medica Brasileira - Category: General Medicine Source Type: research
New research reveals that the only two medications approved for pediatric type 2 diabetes do not prevent rapid progression of prediabetes or recent onset type 2 diabetes in young people with the disease; however, analyses comparing metabolic tests of adults in a companion study and the youth study participants are helping scientists understand how the disease differs with age, which may one day lead to better treatment approaches.
Source: NIDDK News - Category: Endocrinology Source Type: news
Conditions:   Type 2 Diabetes Mellitus;   Mild Cognitive Impairment Interventions:   Dietary Supplement: mediterranean diet;   Behavioral: individualized fitness program;   Other: recommended modified pharmacological treatment Sponsor:   Umeå University Not yet recruiting
Source: - Category: Research Source Type: clinical trials
Experts have issued a new set of guidelines on the best ways to prevent first heart attacks, strokes and heart failure — and for the first time, they focus squarely on the patient. The new guidelines recognize how doctors can support people to not only address their medical risk factors, but also to change their behaviors and lifestyles in order to reduce their risk. The latest revisions to the guidelines, issued by the American College of Cardiology (ACC) and the American Heart Association (AHA), were announced at the annual meeting of the ACC. They are intended to help doctors figure out a patient’s risk of h...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized Heart Disease Source Type: news
GI Dynamics (ASX:GID) said a retrospective study of its EndoBarrier device for patients with type 2 diabetes and obesity shows a significant reduction in HbA1c, weight, liver fat and cardiovascular disease (CVD) risks as well as a reduction in the need for insulin in some patients. The EndoBarrier device is a plastic gut sleeve designed to prevent the absorption of nutrients from food as it exits the stomach and enters the intestinal tract, according to the Lexington, Mass.-based company. Get the full story on our sister site, Medical Design &Outsourcing. The post GI Dynamics touts results of U.K. study appeared first on MassDevice.
Source: Mass Device - Category: Medical Devices Authors: Tags: Blog Business/Financial News Clinical Trials Diabetes Featured News Well Research & Development Surgical Source Type: news
Publication date: Available online 18 March 2019Source: Meta GeneAuthor(s): Shania Abidi Nee Abbas, Syed Tasleem Raza, Snober S. Mir, Zeba Siddiqi, Alina Zaidi, ZeashanHaider Zaidi, Farzana MahdiAbstractBackgroundDiabetes mellitus is a metabolic disorder which can affects the body's ability to produce or use of the hormone insulin leads to high blood sugar levels and it may serves as a host of complications. Emerging evidence suggests that common and rare genetic polymorphisms can influence the risk of developing diabetic complications. We attempt to evaluate the association of (rs7903146 and rs290487) variants of TCF7L2 g...
Source: Meta Gene - Category: Genetics & Stem Cells Source Type: research
(CNN) — If you’re a healthy older adult looking for ways to reduce your risk of heart attack and stroke, don’t turn to that age-old standby: daily low-dose aspirin. It’s no longer recommended as a preventative for older adults who don’t have a high risk or existing heart disease, according to guidelines announced Sunday by the American College of Cardiology and the American Heart Association. “For the most part, we are now much better at treating risk factors such as hypertension, diabetes and especially high cholesterol,” said North Carolina cardiologist Dr. Kevin Campbell, who wa...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - Category: Consumer Health News Authors: Tags: Health News aspirin CNN Source Type: news
DIABETES type 2 symptoms can include unexplained weight loss, feeling very tired, and passing more urine than normal. But you could also be at risk of high blood sugar if you have this one sexual sign. Should you check your blood sugar levels?
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
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