Prenylated indole alkaloids from the stem bark of Hexalobus monopetalus

Publication date: June 2016 Source:Phytochemistry Letters, Volume 16 Author(s): Evelyn Afua Mireku, Merlin L.K. Mensah, Abraham Yeboah Mensah Seven new prenylated indole alkaloids (1–7) together with two known compounds (8–9) were isolated from the stem bark of Hexalobus monopetalus. Their structures were established on the basis of comprehensive spectroscopic analysis, including HR-MS, 1D and 2D NMR and by comparison of their spectral data with those reported in literature. The new compounds were tested for antimicrobial activity against selected pathogenic bacteria and fungi but showed no activity. The marked presence of prenylated indole alkaloids in Hexalobus and closely related genera makes them useful chemotaxonomic markers. Graphical abstract

Source: Phytochemistry Letters - April 2, 2016 Category: Chemistry Source Type: research