Fine-tuning between BMP and NF-κB pathways regulates osteoblastic bone formation

Conclusion p65 inhibits BMP2-induced osteoblastic bone formation by interfering with DNA binding of the Smad complex via an interaction with Smad4. Thus, targeting the association between p65 and Smad4 may help promote bone regeneration in the treatment of bone diseases.
Source: Journal of Oral Biosciences - Category: Biomedical Science Source Type: research