DNA binding to SMC ATPases--trapped for release

The SMC/Rad50/RecN proteins are universal DNA-associated ABC-type ATPases with crucial functions in genome maintenance. New insights into Rad50–DNA complex structure and cohesin regulation inspire a speculative look at the entire superfamily. Identification of a continuous DNA binding site across the Rad50 dimer interface (Liu et al, 2016; Seifert et al, 2016) suggests a similar site in cohesin. The localization of this site hints a DNA-activated mechanism for cohesin removal from chromosomes.
Source: EMBO Journal - Category: Molecular Biology Authors: Tags: Cell Cycle, DNA Replication, Repair & Recombination News [amp ] Views Source Type: research

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Publication date: Available online 18 November 2019Source: Life SciencesAuthor(s): Juan Zhen, Haitao Yu, Honglei Ji, Lu Cai, Jiyan Leng, Bradley B. KellerAbstractDoxorubicin (DOX) induced cardiotoxicity is a life-threatening side effect of chemotherapy and decreased cardiac function can present years after treatment. Despite the investigation of a broad range of pharmacologic interventions, to date the only drug shown to reduce DOX-related cardiotoxicity in preclinical studies and limited clinical trials is the iron chelating agent, dexrazoxane (DRZ), although the mechanisms responsible for DRZ mediated protection from DOX...
Source: Life Sciences - Category: Biology Source Type: research
Sustained, indolent immune injury of the vasculature of a heart transplant limits long-term graft and recipient survival. This injury is mitigated by a poorly characterized, maladaptive repair response. Vascular endothelial cells respond to proangiogenic cues in the embryo by differentiation to specialized phenotypes, associated with expression of apelin. In the adult, the role of developmental proangiogenic cues in repair of the established vasculature is largely unknown. We found that human and minor histocompatibility–mismatched donor mouse heart allografts with alloimmune-mediated vasculopathy upregulated express...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
Authors: Apostu D, Lucaciu O, Mester A, Oltean-Dan D, Baciut M, Baciut G, Bran S, Onisor F, Piciu A, Pasca RD, Maxim A, Benea H Abstract Articular cartilage has a complex structure and metabolism which allow for a proper movement within joints. Nevertheless, several systemically administered pharmacological agents have been proved to improve the anabolic response in the case of cartilage lesions. Alendronate, glucosamine, chondroitin sulfate, hyaluronic acid, collagen hydrolysate, vitamin C, vitamin D, aspirin and strontium ranelate have shown positive results in clinical trials. On the other hand, calcitonin, rise...
Source: Drug Metabolism Reviews - Category: Drugs & Pharmacology Tags: Drug Metab Rev Source Type: research
ConclusionsIn radial nerve injuries, successful results can be achieved with tendon transfer. All patients regained thumb abduction of up to approximately 60 °. All the patients were able to bend the wrist, grip, and extend the fingers while in wrist flexion, neutral wrist and wrist extension positions. Although the reason for the radial injury varied, the postoperative outcomes were good for all patients, and the rehabilitation period progressed succes sfully in patients who underwent tendon transfer repair within 90 days of injury.
Source: Military Medical Research - Category: International Medicine & Public Health Source Type: research
Authors: Roshangar L, Soleimani Rad J, Kheirjou R, Reza Ranjkesh M, Ferdowsi Khosroshahi A Abstract Burn wounds are one of the main causes of skin damage. Based on World Health Organization statistics, almost 300 000 people worldwide die of burns each year. In severe burns, the cells and blood vessels are often injured and the blood supply to the wound is disturbed. Many factors such as oxygenation, infection, aging, hormones, and nutrition potentially can influence burn progression and disrupt repair with unbalanced release of various growth factors and cytokines. Different treatment approaches such as dressings a...
Source: Wounds - Category: General Medicine Tags: Wounds Source Type: research
This study is helpful to evaluate the properties of graphene in an oxygen-rich environment. At the same time, it has certain significance for the application of graphene in band gap engineering.
Source: Physica E: Low dimensional Systems and Nanostructures - Category: Nanotechnology Source Type: research
Publication date: 1 February 2020Source: Materials Chemistry and Physics, Volume 241Author(s): Vahid Zarghami, Mohammad Ghorbani, Kamran Pooshang Bagheri, Mohammad Ali ShokrgozarAbstractBioactive glass has been used clinically in bone repair applications for bone grafting because of its prominent physiochemical and osteogenic properties. Various attempts have been made to enhance bioactive glass efficiency in combination with other biomaterials such as antibiotics and growth factors. In present study, we developed a modification of bioactive glass nanoparticles that insured long term antibacterial effect. Bioactive glass n...
Source: Materials Chemistry and Physics - Category: Materials Science Source Type: research
Conditions:   Rectal Adenocarcinoma;   Clinical Stage: Stage II (T3-4, N-);   Stage III (Any T, N+) Interventions:   Drug: TSR-042;   Drug: capecitabine;   Radiation: Intensity Modulated Radiation Therapy (IMRT) Sponsors:   Memorial Sloan Kettering Cancer Center;   Tesaro, Inc. Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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Source: SafetyLit - Category: International Medicine & Public Health Tags: Economics of Injury and Safety, PTSD, Injury Outcomes Source Type: news
Scientists have discovered a way to manipulate the body ’ s own immune response to help boost tissue repair. The findings, published in Current Biology today [Monday 18 November], reveal a new network of protective factors to shield cells against damage. This discovery, made by University of Bristol researchers, could significantly benefit patients undergoing surgery by speeding recovery times and lowering the risk of complication.
Source: University of Bristol news - Category: Universities & Medical Training Tags: Research, Health, International; Faculty of Life Sciences, Faculty of Life Sciences, School of Biochemistry; Press Release Source Type: news
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