Targeting of tubulin polymerization and induction of mitotic blockage by Methyl 2-(5-fluoro-2-hydroxyphenyl)-1H-benzo[d]imidazole-5-carboxylate (MBIC) in human cervical cancer HeLa cell

Microtubule Targeting Agents (MTAs) including paclitaxel, colchicine and vinca alkaloids are widely used in the treatment of various cancers. As with most chemotherapeutic agents, adverse effects and drug resi...

Source: Journal of Experimental and Clinical Cancer Research - March 31, 2016 Category: Cancer & Oncology Authors: Mohadeseh Hasanpourghadi, Chandrabose Karthikeyan, Ashok Kumar Pandurangan, Chung Yeng Looi, Piyush Trivedi, Kinue Kobayashi, Kozo Tanaka, Won Fen Wong and Mohd Rais Mustafa Source Type: research