Perspective Nursing the oocyte

The generation of a mature egg, or oocyte, is essential for fertility. The oocyte requires the production of considerable quantities of messenger RNA (mRNA), protein, and organelles during its formation, a store needed for the subsequent development of the fertilized egg. In some species, these components are provided by neighboring cells called nurse cells (1). The role of nurse cells during oocyte development has been well studied in the fruit fly, Drosophila melanogaster, but it has been unclear if mammalian species also have nurse cells. On page 95 of this issue, Lei and Spradling (2) provide evidence for nurse cells during mouse oogenesis, adding to our understanding of mammalian oocyte development and raising hope for new infertility treatments. Author: Melissa E. Pepling
Source: ScienceNOW - Category: Science Authors: Tags: Development Source Type: news

Related Links:

AbstractThe production of functional spermatozoa through spermatogenesis requires a spatially and temporally highly regulated gene expression pattern, which in case of alterations, leads to male infertility. Changes of gene expression by chromosome anomalies, gene variants, and epigenetic alterations have been described as the main genetic causes of male infertility. Recent molecular and cytogenetic approaches have revealed that higher order chromosome positioning is essential for basic genome functions, including gene expression. This review addresses this issue by exposing well-founded evidences which support that altera...
Source: Journal of Assisted Reproduction and Genetics - Category: Reproduction Medicine Source Type: research
Testosterone levels vary depending on a person ’s sex, age, and physical activity levels. Testosterone levels that are too high or too low may cause a range of potential complications including infertility and polycystic ovary syndrome (PCOS). Learn more about testosterone levels here.
Source: Health News from Medical News Today - Category: Consumer Health News Tags: Endocrinology Source Type: news
Conditions:   Cancer;   Hematologic Disorder;   Infertility;   Ovarian Failure Intervention:   Other: Ovarian Cryopreservation Sponsor:   St. Justine's Hospital Not yet recruiting
Source: - Category: Research Source Type: clinical trials
Reproduction in Domestic Animals,Volume 0, Issue ja, -Not available-.
Source: Reproduction in Domestic Animals - Category: Reproduction Medicine Authors: Source Type: research
Source: Human Fertility - Category: Reproduction Medicine Authors: Source Type: research
ConclusionMACS is capable of reducing the proportion of SDF, especially spermatozoa with a highly degraded DNA molecule. However, this reduction did not preclude the presence of a small subpopulation of spermatozoa with damaged DNA in the MACS − fraction. The MACS protocol was two- to threefold more efficient when the SDF in NEAT ejaculate was equal to or greater than 30%. In 4 of 20 individuals, the level of SDF after MACS resulted in semen for ICSI with a higher or non-significant reduction when compared to SDF observed in the NEAT ej aculate.
Source: Journal of Assisted Reproduction and Genetics - Category: Reproduction Medicine Source Type: research
Authors: Han Y, Luo H, Zhang Y Abstract This retrospective cohort study aimed to analyse the risk of congenital anomalies (CAs) in infants conceived by infertile women through assisted reproductive technology (ART). A total of 9,013 clinical pregnancy cycles resulting in 9,101 live births between 2004 and 2014 were analysed. Congenital anomalies were evaluated and compared with spontaneous pregnancies in infertile women. A total of 9,101 infants were born following ART. Three subgroups were established: In vitro fertilisation fresh embryo transfer (IVF-ET), n=2,919, intracytoplasmic sperm injection fresh embryo tra...
Source: Experimental and Therapeutic Medicine - Category: General Medicine Tags: Exp Ther Med Source Type: research
Authors: Wang X, Ding X, Xiao X, Xiong F, Fang R Abstract The aim of the present study was to explore the influence of positive simple thyroid peroxidase antibody (TPO-Ab) on female infertility. Venous blood was collected on an empty stomach from infertile female patients (all of whom were in line with the World Health Organization's diagnostic criteria for infertility) receiving treatments at The Affiliated Wuxi Maternity and Child Health Care Hospital of Nanjing Medical University from 2014 to 2017 to detect thyroid function and thyroid antibodies [thyroglobulin antibody (TG-Ab), TPO-Ab and thyroid microsome anti...
Source: Experimental and Therapeutic Medicine - Category: General Medicine Tags: Exp Ther Med Source Type: research
AbstractBackground The European Society of Human Reproduction and Embryology –European Society for Gynaecological Endoscopy (ESHRE–ESGE) system is designed mainly for clinical orientation; its overdiagnosis of septate uteri was confirmed in a general population in comparison to the American Society of Reproductive Medicine (ASRM) supplemental classification proposed by L udwin. However, the agreement among septate uterus recognition using the ESHRE–ESGE and the supplemental ASRM classifications and the rate of overdiagnosis of septate uterus by ESHRE-ESGE in infertile women remain unclear.MethodsWe cond...
Source: Archives of Gynecology and Obstetrics - Category: OBGYN Source Type: research
ConclusionIn light of connecting etiological link between infertility and RM as reviewed in this study, interrogating the oocyte-specific genes with suspected roles in reproductive biology, in cases of unexplained RM, may open new possibilities in widening our understanding of RM pathophysiology.
Source: Journal of Assisted Reproduction and Genetics - Category: Reproduction Medicine Source Type: research
More News: Infertility | Nurses | Nursing | Reproduction Medicine | Science