In Depth Brazil bill would legalize renegade cancer pill

A showdown over a controversial cancer therapy has intensified, pitting Brazil's scientists against its congress. Last week, responding to a clamor from politicians and desperate patients, the congress voted to legalize the production and distribution of synthetic phosphoethanolamine, even though the putative cancer drug has not been clinically tested or registered with the Brazilian Health Surveillance Agency. Scientists blast the legislation as a travesty. Apart from patient testimonials and a few preliminary studies in tumor cell lines and in mice, critics say, there is no evidence of the safety or efficacy of the compound, popularly known as the "cancer pill" or "fosfo." Several thousand patients are estimated to have taken it. Brazilian President Dilma Rousseff has until 13 April to decide whether to sign the bill into law. Author: Herton Escobar
Source: ScienceNOW - Category: Science Authors: Tags: Cancer Research Source Type: news

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Authors: Gallicchio R, Mastrangelo PA, Nardelli A, Mainenti PP, Colasurdo AP, Landriscina M, Guglielmi G, Storto G Abstract Radium-223 dichloride (223Ra) is the first, recently approved, α-particle-emitting radiopharmaceutical for the treatment of patients with bone metastases in castration-resistant prostate cancer (CRPC) and no evidence of visceral metastases. We explored MEDLINE, relevant congresses, and websites for data on 223Ra and prostate cancer therapies, focusing on therapeutic strategies and timing, bone metastases, and diagnostic assessment. 223Ra represents the only bone-targeting agent that has ...
Source: Tumori - Category: Cancer & Oncology Tags: Tumori Source Type: research
Abstract The development of resistance toward current cancer therapy modalities is an ongoing challenge in gynecological cancers, especially ovarian and cervical malignancies that require further investigations in the context of drug- and irradiation-induced resistance. In this regard, curcumin has demonstrated beneficial and highly pleiotropic actions and increased the therapeutic efficiency of radiochemotherapy. The antiproliferative, anti-metastatic, anti-angiogenic, and anti-inflammatory effects of curcumin have been extensively reported in the literature, and it could also act as a chemopreventive agent which...
Source: Pharmacological Reviews - Category: Drugs & Pharmacology Authors: Tags: Rev Physiol Biochem Pharmacol Source Type: research
AbstractPurpose of reviewThe emerging complexity of cardiac toxicity caused by cancer therapies has created demand for more advanced non-invasive methods to better evaluate cardiac structure, function, and myocardial tissue characteristics. Cardiac magnetic resonance imaging meets these needs without exposure to ionizing radiation, and with superior spatial resolution.Recent findingsSpecial applications of cardiac magnetic resonance (CMR) to assess for cancer therapy –induced cardiac toxicity include the detection of subclinical LV dysfunction through novel methods of measuring myocardial strain, detection of microci...
Source: Current Treatment Options in Cardiovascular Medicine - Category: Cardiology Source Type: research
Authors: Chen L, König B, Liu T, Pervaiz S, Razzaque YS, Stauber T Abstract The volume-regulated anion channel (VRAC) is a key player in volume regulation of vertebrate cells. This ubiquitously expressed channel opens upon osmotic cell swelling and potentially other cues and releases chloride and organic osmolytes, which contributes to regulatory volume decrease (RVD). A plethora of studies proposed a wide range of physiological roles for VRAC beyond volume regulation including cell proliferation, differentiation and migration, apoptosis, intercellular communication by direct release of signaling molecules and...
Source: Biological Chemistry - Category: Chemistry Tags: Biol Chem Source Type: research
This study might provide a new insight to understand the pathogenesis of melanoma and possibly contributed to development of therapeutic approaches for melanoma.Graphical abstract
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research
In this study, poly lactic-co-glycolic acid nanoparticles (NPs) were used as DC antigen delivery vehicles in a preclinical model of immunotherapy of gastric cancer. The DCs were generated from peripheral blood monocytes by conventional in vitro differentiation and loaded with either soluble tumor lysate or lysate encapsulated in NPs using a double emulsion/solvent evaporation technique. Morphology of NPs was determined by scanning electron microscopy. Tumor lysate, either in the soluble form or encapsulated in NPs, was loaded into DC and stimulatory capacity was compared using patient-derived autologous CD3+ T cells as res...
Source: Immunological Investigations - Category: Allergy & Immunology Tags: Immunol Invest Source Type: research
Phys. Chem. Chem. Phys., 2019, Accepted Manuscript DOI: 10.1039/C9CP02024A, PaperTianli Xie, Jie Yu, Weitao Fu, Zhe Wang, Lei Xu, Shan Chang, Ercheng Wang, Su Zeng, Feng Zhu, Yu Kang, Tingjun Hou DNA methyltransferases (DNMTs), responsible for regulation of DNA methylation, have been regarded as promising drug targets for cancer therapy. However, high structural conservation of the catalytic domains of DNMTs poses... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Phys. Chem. Chem. Phys. latest articles - Category: Chemistry Authors: Source Type: research
AbstractThe tumor microenvironment (TME) has drawn considerable research attention as an alternative target for nanomedicine-based cancer therapy. Various nanomaterials that carry active substances have been designed to alter the features or composition of the TME and thereby improve the delivery and efficacy of anticancer chemotherapeutics. These alterations include disruption of the extracellular matrix and tumor vascular systems to promote perfusion or modulate hypoxia. Nanomaterials have also been used to modulate the immunological microenvironment of tumors. In this context, nanomaterials have been shown to alter popu...
Source: The AAPS Journal - Category: Drugs & Pharmacology Source Type: research
SummaryImmuno-oncology and in particular checkpoint inhibitor (CPI) treatment has become a  novel promising cancer therapy strategy in recent years. However, still a minority of patients respond to checkpoint blockade. Primary and secondary resistance to CPI is a challenge in the daily clinical routine. Combination strategies have been tested in various clinical trials in order to addr ess this issue. Data available from these trials indicate improved activity depending on the tumor type. This review article focuses on the molecular background for resistance to CPI, gives an overview of current clinical data...
Source: Memo - Magazine of European Medical Oncology - Category: Cancer & Oncology Source Type: research
CONCLUSION: For years the FDA-approved, well-tolerated, inexpensive, orally-administered drug Disulfiram was used in the treatment of chronic alcoholism, but it has recently demonstrated anti-cancer effects in a range of solid and hematological malignancies. Its combination with clinically relevant copper concentrations might overcome the resistance of many anti-cancer drugs in vitro, in vivo, and in patients. PMID: 31084595 [PubMed - as supplied by publisher]
Source: Recent Patents on Anti-Cancer Drug Discovery - Category: Cancer & Oncology Tags: Recent Pat Anticancer Drug Discov Source Type: research
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