New drug for the treatment of rheumatoid arthritis shows promising success

In a clinical phase-3-study, an international research cooperation has achieved significant success with the drug Baricitinib for the treatment of rheumatoid arthritis. The test persons exhibited significantly less symptoms of the disorder.
Source: ScienceDaily Headlines - Category: Science Source Type: news

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Authors: Leng P, Li D, Sun Y, Wang Y, Zhang H Abstract The aim of the study is to screen the effective shRNA sequence which can silence the human COX-2 expression level in synovial cells of rheumatoid arthritis (RA) patient transfected by the lentivirus. Four pairs of hCOX-2 shRNA were designed and inserted into lentivirus to form pGPHI/GFP/Neo-shRNA vector. The reconstructed virus was transfected into synovial cells derived from RA patients, and then the expression level of hCOX-2 mRNA and the protein of the inflammatory factors including prostaglandin E2 (PGE2), vascular endothelial growth factor (VEGF), interleu...
Source: Artificial Cells, Nanomedicine and Biotechnology - Category: Biotechnology Tags: Artif Cells Nanomed Biotechnol Source Type: research
A recent study suggests Zilretta, an intra-articular injection for OA knee pain, may lower blood glucose levels in OA patients...
Source: The Rheumatologist - Category: Rheumatology Authors: Tags: Analgesics Biologics & Biosimilars Drug Updates blood glucose filgotinib Knee Osteoarthritis (OA) knee pain Rheumatoid Arthritis (RA) Zilretta Source Type: research
Publication date: Available online 15 October 2018Source: Arthroscopy TechniquesAuthor(s): Nicholas Elena, Brittany M. Woodall, Katie Lee, Patrick J. McGahan, Neil P. Pathare, Edward C. Shin, James L. ChenAbstractSubchondral lesions are the result of osseous modifications seen in a different array of pathologies such as osteoarthritis, rheumatoid arthritis, calcium pyrophosphate deposition, and osteonecrosis. The physiopathologic changes in all of the aforementioned pathologies are not clear yet. What is clear is that the development of a cystic change in the subchondral bone can cause pain and can lead to modification of ...
Source: Arthroscopy Techniques - Category: Surgery Source Type: research
AbstractTo evaluate the association between sudden sensorineural hearing loss (SSNHL) and rheumatoid arthritis (RA) among a national sample cohort from Korea. Data were collected from 2002 through 2013 for individuals aged ≥ 20 years in the Korean National Health Insurance Service (NHIS)-National Sample Cohort. We extracted the data from RA patients (n = 7619) and 1:4-matched controls (n = 30,476) and analyzed the occurrence of SSNHL. Matching was performed based on age, sex, income, region of residence, and medical history. RA was diagnosed based on International Classification o...
Source: Clinical Rheumatology - Category: Rheumatology Source Type: research
AbstractTo assess the persistence of golimumab and other tumour necrosis factor- α inhibitors (TNFis) in patients with rheumatoid arthritis (RA), ankylosing spondylitis (AS) and psoriatic arthritis (PsA) in Slovenia. We analysed prospectively the collected data of all patients treated with golimumab and other TNFis from 1 January 2010 to 31 July 2018 from the mandatory national BioRx.si registry. We assessed the treatment persistence stratified by treatment type, indication and prior exposure to bDMARDs using the Kaplan-Meier method and Cox proportional regression hazards’ models adjusted for the well-appreciat...
Source: Clinical Rheumatology - Category: Rheumatology Source Type: research
Journal of Clinical Laboratory Analysis, EarlyView.
Source: Journal of Clinical Laboratory Analysis - Category: Laboratory Medicine Authors: Source Type: research
AbstractThe immune system and bone metabolism influence each other. An imbalance in the immune system, resulting in inflammatory stimuli may induce an imbalance in bone turnover via induction of osteoclast differentiation and inhibition of osteoblast differentiation, leading to various pathological conditions including osteoporosis. T-cell subsets, helper T (Th)1 and Th17, which activate the immune system, induce osteoclasts, whereas regulatory T (Treg) cells, responsible for immunosuppression, inhibit osteoclastic differentiation. In addition, inflammatory cytokines, such as the tumor necrosis factor (TNF), also cause an ...
Source: Journal of Bone and Mineral Metabolism - Category: Orthopaedics Source Type: research
Authors: Woolston W, Connelly LM Abstract Felty's syndrome is a triad of rheumatoid arthritis, splenomegaly, and neutropenia. This rare disorder is difficult to diagnose and produces many complications. The purpose of this descriptive qualitative case study was to provide a comprehensive, context-bound understanding of one patient's struggle with the condition. PMID: 30304590 [PubMed]
Source: Medsurg Nursing : Official Journal of the Academy of Medical-Surgical Nurses - Category: Nursing Tags: Medsurg Nurs Source Type: research
Authors: Sun WH, Dai SP Abstract Rheumatoid arthritis (RA), characterized by chronic inflammation of synovial joints, is often associated with ongoing pain and increased pain sensitivity. Chronic pain that comes with RA turns independent, essentially becoming its own disease. It could partly explain that a significant number (50%) of RA patients fail to respond to current RA therapies that focus mainly on suppression of joint inflammation. The acute phase of pain seems to associate with joint inflammation in early RA. In established RA, the chronic phase of pain could be linked to inflammatory components of neuron-...
Source: Advances in Experimental Medicine and Biology - Category: Research Tags: Adv Exp Med Biol Source Type: research
Publication date: Available online 10 October 2018Source: Joint Bone SpineAuthor(s): Claire Daien, Charlotte Hua, Cécile Gaujoux-Viala, Alain Cantagrel, Madeleine Dubremetz, Maxime Dougados, Bruno Fautrel, Xavier Mariette, Nathalie Nayral, Christophe Richez, Alain Saraux, Gérard Thibaud, Daniel Wendling, Laure Gossec, Bernard CombeAbstractThe 2014 French Society for Rheumatology (Société Française de Rheumatologie, SFR) recommendations about the management of rheumatoid arthritis (RA) have been updated by a task force composed of 12 expert rheumatologists, 2 patient self-help group repres...
Source: Joint Bone Spine - Category: Orthopaedics Source Type: research
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