New drug for the treatment of rheumatoid arthritis shows promising success

In a clinical phase-3-study, an international research cooperation has achieved significant success with the drug Baricitinib for the treatment of rheumatoid arthritis. The test persons exhibited significantly less symptoms of the disorder.
Source: ScienceDaily Headlines - Category: Science Source Type: news

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AbstractThe aim of this study was to examine whether the vitamin D level is causally associated with risk of systemic lupus erythematosus (SLE) or rheumatoid arthritis (RA). We performed two-sample Mendelian randomization (MR) analyses using the inverse-variance weighted (IVW), weighted median, and MR-Egger regression methods on publicly available summary statistics datasets using two vitamin D level genome-wide association studies (GWASs) as exposure and SLE and RA GWASs on people of European descent as outcomes. We selected three independent single-nucleotide polymorphisms located at SSTR4 (rs2207173), GC (rs2282679), an...
Source: Clinical Rheumatology - Category: Rheumatology Source Type: research
This study aimed to assess the incidence of active TB and the efficacy of TB prevention measures used over the years, and to determine risk factors for developing TB, in a single-centre cohort of patients with rheumatoid arthritis (RA), psoriatic arthritis (PsA) and ankylosing spondylitis (AS) receiving TNFi. Data of all patients in whom treatment with TNFi was initiated in our rheumatology clinic until December 1st 2014 have been retrospectively analysed. The cohort was divided into 3 groups per the mandatory LTBI screening method at baseline: tuberculin skin test (TST) with a positive threshold of either 10  mm (gro...
Source: Clinical Rheumatology - Category: Rheumatology Source Type: research
Condition:   Rheumatoid Arthritis (RA) Intervention:   Diagnostic Test: Vectra DA Sponsor:   Myriad Genetic Laboratories, Inc. Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Childhood exposure to secondhand smoke might raise women’s risk of developing rheumatoid arthritis, new research finds.
Source: WebMD Health - Category: Consumer Health News Source Type: news
ConclusionsAlthough these results suggest that control of inflammation could have a beneficial effect on the lipid profile through an increase in HDL cholesterol levels, the observed protective effect on cardiovascular disease events by tumor necrosis factor blockers is likely to be explained by other mechanisms than changes in lipid levels or short-term effects on atherosclerosis of the carotid artery.
Source: Current Therapeutic Research - Category: Drugs & Pharmacology Source Type: research
Publication date: Available online 14 August 2018Source: Autoimmunity ReviewsAuthor(s): Kassem Sharif, Abdulla Watad, Louis Coplan, Benjamin Lichtbroun, Alec Krosser, Michael Lichtbroun, Nicola Luigi Bragazzi, Howard Amital, Arnon Afek, Yehuda ShoenfeldAbstractStress is defined as the pscyophysiological reaction in which the steady state is disturbed or threatened. Stress is not always perceived as a negative response. Stress results when environmental demands exceed an individuals' adaptive capacities. Autoimmune diseases are heterogeneous group of chronic diseases which occur secondary to loss of self antigen tolerance. ...
Source: Autoimmunity Reviews - Category: Allergy & Immunology Source Type: research
Persistent cytomegalovirus (CMV) infection is thought to cause a sizable amount of the age-related decline of the immune system. Latent infection by this sort of herpesvirus causes few to no immediate and obvious symptoms in the vast majority of individuals, but the virus cannot be permanently cleared by the immune system. Over time ever more T cells of the adaptive immune system become uselessly specialized to CMV, unavailable for other tasks. Coupled with the much reduced pace of creation of new T cells in later life, this results in an increasingly dysfunctional immune system. Researchers here point to one specif...
Source: Fight Aging! - Category: Research Authors: Tags: Daily News Source Type: blogs
Authors: Okuda Y, Yamada T, Ueda M, Ando Y Abstract Objective To clarify the underlying diseases, clinical manifestations, and treatment strategies for AA amyloidosis (AAA) in Japanese patients. Methods We conducted a survey on Japanese patients with AAA treated between January 1, 2012, and December 31, 2014. Results A total of 199 patients with AAA were included in the present study. The underlying diseases of AAA were rheumatoid arthritis (60.3%), uncharacterized inflammatory disorders (11.1%), neoplasms (7.0%), other rheumatic diseases (6.5%), inflammatory bowel diseases (4.5%), chronic infection (4.5%), Castlem...
Source: Internal Medicine - Category: Internal Medicine Tags: Intern Med Source Type: research
Researchers have determined that dominant B cell receptor (BCR) clones in peripheral blood may predict the onset of clinical signs and symptoms of RA...
Source: The Rheumatologist - Category: Rheumatology Authors: Tags: Conditions Rheumatoid Arthritis B cell receptor clones B cells Rheumatoid Arthritis (RA) Source Type: research
WEDNESDAY, Aug. 15, 2018 -- Women who were regularly exposed to secondhand smoke as children might be at slightly increased risk of rheumatoid arthritis, a new study hints. Rheumatoid arthritis is an autoimmune disease in which the immune system...
Source: Drugs.com - Daily MedNews - Category: General Medicine Source Type: news
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