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New drug for the treatment of rheumatoid arthritis shows promising success

In a clinical phase-3-study, an international research cooperation has achieved significant success with the drug Baricitinib for the treatment of rheumatoid arthritis. The test persons exhibited significantly less symptoms of the disorder.
Source: ScienceDaily Headlines - Category: Science Source Type: news

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Authors: Hagihara M, Mese T, Ohara S, Hua J, Ide S, Inoue M Abstract we herein report a rare case of methotrexate (MTX)-associated intravascular large B-cell lymphoma (IVLBCL) in a man with rheumatoid arthritis. Two episodes of a fever of unknown origin accompanied by elevated levels of serum lactate dehydrogenase and the soluble interleukin-2 receptor occurred within a year, so the patient was suspected of having an MTX-associated lymphoproliferative disorder. His clinical symptoms resolved after the cessation of MTX. However, after treatment with iguratimod, another disease-modified anti-rheumatic drug, markedly ...
Source: Internal Medicine - Category: Internal Medicine Tags: Intern Med Source Type: research
Conclusions In this subset analysis, RA patients from Argentina treated with adalimumab or infliximab, but not etanercept, tested positive for ADAs. Antidrug antibody–negative patients showed a tendency toward better clinical outcomes compared with ADA-positive patients.
Source: JCR: Journal of Clinical Rheumatology - Category: Rheumatology Tags: Original Articles Source Type: research
Conclusions Novel data streams and big data analytics are effective to assess the impact of a disease in a famous person on the laypeople.
Source: JCR: Journal of Clinical Rheumatology - Category: Rheumatology Tags: Original Articles Source Type: research
This study reports the effect of disease-modifying therapies for rheumatoid arthritis (RA) on systolic and diastolic blood pressure (SBP, DBP) over 6 months and incident hypertension over 3 years in a large administrative database. Methods We used administrative Veterans Affairs databases to define unique dispensing episodes of methotrexate, leflunomide, sulfasalazine, hydroxychloroquine, tumor necrosis factor inhibitors, and prednisone among patients with RA. Changes in SBP and DBP in the 6 months before disease-modifying antirheumatic drug initiation were compared with changes observed in the 6 months after initiation...
Source: JCR: Journal of Clinical Rheumatology - Category: Rheumatology Tags: Original Articles Source Type: research
Conclusions Regardless of BP magnitude, most RA clinic visits lacked documented communication about BP despite compounded CVD risk. Future work should study how rheumatology clinics can facilitate follow-up of high BPs to address HTN as the most common and reversible CVD risk factor.
Source: JCR: Journal of Clinical Rheumatology - Category: Rheumatology Tags: Original Articles Source Type: research
No abstract available
Source: JCR: Journal of Clinical Rheumatology - Category: Rheumatology Tags: Letters to the Editor Source Type: research
Publication date: Available online 23 April 2018 Source:Trends in Pharmacological Sciences Author(s): Marveh Rahmati, Mohammad Amin Moosavi, Michael F. McDermott Diverse physiological and pathological conditions that impact on protein folding of the endoplasmic reticulum (ER) cause ER stress. The unfolded protein response (UPR) and the ER-associated degradation (ERAD) pathway are activated to cope with ER stress. In rheumatoid arthritis (RA), inflammation and ER stress work in parallel by driving inflammatory cells to release cytokines that induce chronic ER stress pathways. This chronic ER stress may contribute to the pa...
Source: Trends in Pharmacological Sciences - Category: Drugs & Pharmacology Source Type: research
TUESDAY, May 22, 2018 -- Offspring born to mothers with rheumatoid arthritis (RA) who are exposed to tumor necrosis factor α inhibitors (TNFi) in the gestational period do not have a significantly increased risk of serious infections, according to...
Source: Drugs.com - Pharma News - Category: Pharmaceuticals Source Type: news
Conclusion: This case report demonstrates a self-peeling ERM associated with a retinal capillary hemangioma. This case contributes the literature describing the natural history of ERMs associated with peripherally located capillary hemangiomas in patients without von Hippel–Lindau disease.
Source: Retinal Cases and Brief Reports - Category: Opthalmology Tags: Case Report Source Type: research
smith&nephew 5o (5 degree) GENESIS(R) II VALGUS BUSHING, REF CATALOG NUMBER 71440014 The GENESIS II Knee System Components are indicated for rheumatoid arthritis; post-traumatic arthritis, osteoarthritis, or degenerative arthritis in older patients whose age, weight, and activity levels are compatible with an adequate long-term result; failed osteotomies, unicompartmental replacement, or total knee replacement. The constrained knee systems are designed for use in patients in primary and revision surgery, where the posterior cruciate ligament and one or both of the collateral ligaments (i.e., medial collateral and/or latera...
Source: Medical Device Recalls - Category: Medical Devices Source Type: alerts
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