Research on 3-D scaffolds sets new bar in lung regeneration

For the estimated 12.7 million people with chronic obstructive pulmonary disorder, the third leading cause of death in the U.S., innovative research efforts in the field of tissue regeneration hold promise. In end-stage lung disease, transplantation is sometimes the only viable therapeutic option, but organ availability is limited and rejection presents an additional challenge. New research focuses on lung tissue bioengineering, which involves the use of a scaffold -- or framework -- of lungs from human cadavers to engineer new lungs for patients with end-stage disease.
Source: ScienceDaily Headlines - Category: Science Source Type: news

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CONCLUSIONS: The terminal bronchioles are relatively preserved while neutrophilic inflammation is increased in PSE-dominant regions compared to CLE-dominant regions in patents with COPD. PMID: 32485111 [PubMed - as supplied by publisher]
Source: American Journal of Respiratory and Critical Care Medicine - Category: Respiratory Medicine Authors: Tags: Am J Respir Crit Care Med Source Type: research
Condition:   Chronic Obstructive Pulmonary Disease Intervention:   Other: Pulmonary Rehabilitation Sponsors:   Klaus Kenn;   Schön Klinik Berchtesgadener Land Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
This study delves into the mechanisms by which a short period of fasting can accelerate wound healing. Fasting triggers many of the same cellular stress responses, such as upregulated autophagy, as occur during the practice of calorie restriction. It isn't exactly the same, however, so it is always worth asking whether any specific biochemistry observed in either case does in fact occur in both situations. In particular, the period of refeeding following fasting appears to have beneficial effects that are distinct from those that occur while food is restricted. Multiple forms of therapeutic fasting have been repor...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Background. Frailty is a clinically recognized syndrome of decreased physiological reserve and a key contributor to suboptimal clinical outcomes in various lung disease groups. Interstitial lung disease (ILD) is fast approaching chronic obstructive pulmonary disease as the number one indication for lung transplantation worldwide. Our aim was to assess whether frailty is a predictor of mortality in patients with ILD referred for lung transplantation in an Australian cohort. Methods. Consecutive patients with ILD referred or on the waiting list for lung transplantation from May 2013 to December 2017 underwent frailty as...
Source: Transplantation - Category: Transplant Surgery Tags: Original Clinical Science—General Source Type: research
Eosinophils are associated with the onset of chronic respiratory diseases like asthma and COPD. In lung transplantation, patients with increased bronchoalveolar lavage eosinophils demonstrated a worse chronic lung allograft dysfunction (CLAD)-free survival and overall survival. We investigated the association between blood eosinophilia, graft survival and CLAD-free survival after lung transplantation.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: (751) Source Type: research
We report outcomes of SLT vs. BLT for COPD at our center.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: (749) Source Type: research
Fatigue is a common symptom experienced by patients with chronic heart and lung failure that can lead to adverse health outcomes, such as frailty. To better understand the nature of fatigue in heart and lung failure, a meta-synthesis of qualitative studies was conducted to explore patients ’ experiences of fatigue while living with heart failure (HF) or chronic obstructive pulmonary disease (COPD). Understanding the nature and impact of fatigue in these chronic conditions can guide the evaluation and management of fatigue and inform future development of therapeutic interventions to decrease fatigue and improve quality of life.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: (1280) Source Type: research
Lung volume reduction surgery (LVRS) is a therapeutic option in the treatment of chronic obstructive pulmonary disease (COPD), the most common indication for lung transplantation (LTx). LVRS prior to LTx is controversial. Single institution studies report contradicting results, and the impact of undergoing LVRS prior to LTx on outcomes after LTx is unclear. We performed a propensity-matched analysis of outcomes after LTx in patients who underwent LVRS using a national database of LTx.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: (927) Source Type: research
Oscillometry (Osc) is a non-invasive test of respiratory impedance that is sensitive to small airways, a region of lung that is not well characterized by conventional pulmonary function tests (PFT) and has been shown to detect chronic obstructive lung disease (COPD) prior to changes in PFT. We posit that Osc could identify small airway obstruction post-lung transplant (LTx) and discriminate between lungs from smoking vs non-smoking donors.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: (763) Source Type: research
Abstract BACKGROUND: Patients with chronic obstructive pulmonary disease (COPD) who develop pulmonary hypertension (PH) have worse mortality than those with COPD alone. Predictors of poor outcomes in COPD-PH are not well described. Diffusing capacity of the lung (DLCO) assesses the integrity of the alveolar-capillary interface and thus may be a useful prognostic tool among those with COPD-PH. RESEARCH QUESTION: Using a single center registry, we sought to evaluate DLCO as a predictor of mortality in a cohort of COPD-PH patients. STUDY DESIGN AND METHODS: This retrospective cohort study analyzed 71 COPD-P...
Source: Chest - Category: Respiratory Medicine Authors: Tags: Chest Source Type: research
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