Identification of Patients Who Benefit From Bevacizumab in High-Grade Glioma--An Easy Question Turned Difficult: Treat the Scan or the Patient? CORRESPONDENCE

Source: Journal of Clinical Oncology - Category: Cancer & Oncology Authors: Tags: CORRESPONDENCE Source Type: research

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AbstractThe grading of glioma has clinical significance in determining a treatment strategy and evaluating prognosis to investigate a novel set of radiomic features extracted from the fractional anisotropy (FA) and mean diffusivity (MD) maps of brain diffusion tensor imaging (DTI) sequences for computer-aided grading of gliomas. This retrospective study included 108 patients who had pathologically confirmed brain gliomas and DTI scanned during 2012 –2018. This cohort included 43 low-grade gliomas (LGGs; all grade II) and 65 high-grade gliomas (HGGs; grade III or IV). We extracted a set of radiomic features, including...
Source: Journal of Digital Imaging - Category: Radiology Source Type: research
ConclusionTo the best of our knowledge this is the first case report demonstrating central nervous system-related bradycardia and syncope without other neurological symptoms. This case will serve as a useful reminder to general practitioners, accident and emergency doctors, and cardiologists.
Source: Journal of Medical Case Reports - Category: General Medicine Source Type: research
ConclusionsThe results reinforce that [18F]FGln has preferential uptake in glioma tissueversus that of corresponding healthy tissue and fits well with reversible uptake models.
Source: Molecular Imaging and Biology - Category: Molecular Biology Source Type: research
Conclusion: Epithelioid GBM is one of the rarest morphologic subtypes of GBM and has a strongly infiltrative and aggressive nature. Therefore, careful identification of preoperative imaging studies and detailed evaluation of genetic studies are necessary to select the appropriate treatment for epithelioid GBM. PMID: 31966927 [PubMed]
Source: Surgical Neurology International - Category: Neurosurgery Tags: Surg Neurol Int Source Type: research
ConclusionsThe change in maximum normalized18F-FDOPA PET uptake, with or without clinical information and rate of change in tumor volume, may be useful for predicting the risk of malignant transformation and estimating residual survival in patients with LGG.
Source: Journal of Neuro-Oncology - Category: Cancer & Oncology Source Type: research
Conditions:   Brain Tumor;   Glioma;   IDH Mutation Intervention:   Device: MR-scans using a 3T Prisma and a 7T Terra scanner (Siemens, Erlangen Germany) Sponsors:   University Hospital Inselspital, Berne;   Swiss National Science Foundation Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
CONCLUSIONS: GDC-0084 demonstrated classic PI3K/mTOR-inhibitor related toxicities. FDG-PET and concentration data from brain tumor tissue suggest that GDC-0084 crossed the blood-brain barrier. PMID: 31937616 [PubMed - as supplied by publisher]
Source: Clinical Cancer Research - Category: Cancer & Oncology Authors: Tags: Clin Cancer Res Source Type: research
ConclusionMalignant transformation occurs locally and within the T2w hyperintensities in most patients. Although LGG is an infiltrating disease, this data conceptually strengthens the role of loco-regional treatments in patients with LGG.
Source: Journal of Neuro-Oncology - Category: Cancer & Oncology Source Type: research
CONCLUSIONS: 11C-methionine PET can noninvasively evaluate the IDH1 mutation status of patients with nonenhancing supratentorial diffuse gliomas. PMID: 31889470 [PubMed - in process]
Source: Molecular Imaging - Category: Radiology Tags: Mol Imaging Source Type: research
O-(2-[18F]fluoroethyl)-l-tyrosine positron-emission tomography/computed tomography (18F-FET PET/CT) is well known in brain tumor management. Our study aimed to identify the prognostic value of 18F-FET PET/CT in high-grade gliomas (HGG) according the current 2016 World Health Organization (WHO) classification. Patients with histologically proven WHO 2016 HGG were prospectively included. A dynamic 18F-FET PET/CT was performed allowing to obtain 2 static PET frames (static frame 1: 20–40 minutes and static frame 2: 2–22 minutes). We analyzed static parameters (standard uptake value [SUV]max, SUVmean, SUVpeak,...
Source: Medicine - Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research
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