The 'Pinhole' Cancer Treatment You've Probably Never Heard of

Imagine an exquisitely precise cancer therapy procedure done through a small opening in the body that can: Kill tumor cells, shrink tumors, or regrow the healthy part of a cancerous organ. Deliver chemotherapy or radiation directly to the cancer site. Usually be done as an outpatient procedure with fewer side effects than conventional treatments like chemotherapy. Potentially treat many types of cancer, either alone or combined with other therapies. Sounds too good to be true, right? Not necessarily, since this type of therapy, called interventional oncology, is now being performed hundreds of times every day by specialists in a medical field that is unfamiliar to many cancer patients. Many predict this fast-growing specialty will soon join medical, surgical and radiation oncology as the fourth pillar of cancer care. Pioneers in Precision Medicine Interventional oncology is an image-guided, minimally invasive surgery done by radiologists that uses imaging scans as maps to identify the location of tumors and blood vessels as pathways to kill tumors or shrink and prepare them for removal. Most procedures are either outpatient or require a brief overnight stay in the hospital. Recovery time is minimal; some patients are active as early as the next day. Plus, there are rarely the physical complications associated with surgery nor the side effects with chemotherapy or external radiation, like hair loss. Interventional oncology is a subset of the field of interventional radiolog...
Source: Science - The Huffington Post - Category: Science Source Type: news

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Publication date: Available online 18 April 2019Source: Actas Dermo-Sifiliográficas (English Edition)Author(s): F.J. Navarro-Triviño, S. Arias-Santiago, Y. Gilaberte-CalzadaAbstractIn recent years, the growing interest in the role played by vitamin D in skin disease has given rise to the publication of many studies of the relationship between this vitamin and certain skin conditions. As dermatologists, we need to understand, among other aspects, how vitamin D is synthesized and the main sources in humans, as well as plasma levels and the factors that can modify them. Of particular interest are the latest disc...
Source: Actas Dermo-Sifiliograficas - Category: Dermatology Source Type: research
(University of Huddersfield) Scientists are developing a specially-formulated shampoo which, combined with scalp cooling innovations, could put an end to the misery for many cancer sufferers.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
Erica S. Tarabadkar† and Michi M. Shinohara*† Division of Dermatology, University of Washington, Seattle, WA, United States Skin directed therapies (SDTs) serve important roles in the treatment of early stage cutaneous T-cell lymphoma (CTCL)/mycosis fungoides (MF), as well as managing symptoms and improving quality of life of all stages. There are now numerous options for topical therapies that demonstrate high response rates, particularly in early/limited MF. Phototherapy retains an important role in treating MF, with increasing data supporting efficacy and long-term safety of both UVB and PUVA as ...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
Xiaoli Fan1†, Dandan Yin2†, Ruoting Men1, Heng Xu2* and Li Yang1* 1Department of Gastroenterology and Hepatology, West China Hospital, Sichuan University, Chengdu, China 2Department of Laboratory Medicine, National Key Laboratory of Biotherapy/Collaborative Innovation Center for Biotherapy and Precision Medicine Key Laboratory of Sichuan Province, West China Hospital, Sichuan University, Chengdu, China The aim of this study was to investigate the influence of NUDT15 R139C and thiopurine S-methyltransferase (TPMT) on azathioprine (AZA) induced leukopenia in patients with autoimmune hepatitis (AIH) a...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
In conclusion, NC-LAP demonstrate antitumoral effect in HER-positive bladder cells by inducing cell cycle arrest and apoptosis exhibiting better effects compared to the non-encapsulated lapatinib. Our work suggests that the LAP loaded in nanoformulations could be a promising approach to treat tumors that presents EGFR overexpression phenotype. Introduction Bladder cancer (BC) is a heterogeneous disease which presents several molecular characteristics associated with different clinical outcomes (1). Urothelial or transitional cell carcinoma (TCC) represent the most frequent type of bladder cancer (2) and are classifie...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
ConclusionsExtending the duration of 90-min post-infusion scalp cooling to 150  min in patients treated with adjuvant FEC chemotherapy was well-tolerated but did not significantly diminish the need for head covering. However, grades 2–3 alopecia was seen less often with prolonged post-infusion scalp cooling.
Source: Supportive Care in Cancer - Category: Cancer & Oncology Source Type: research
Conclusions: Our study demonstrated that combination of 40 mg/m2 PEG-LD and 600 mg/m2 cyclophosphamide, followed by 75 mg/m2 docetaxel on day 1 of a 21-day scheme, was an efficacious and well-tolerated neoadjuvant regimen for patients with locally advanced breast cancer.Oncol Res Treat
Source: Oncology Research and Treatment - Category: Cancer & Oncology Source Type: research
Abstract Sex-related incidence and outcomes were reported in various cancers, including colorectal cancer. 5-Fluorouracil (5-FU) is widely used as an essential chemotherapeutic agent for colorectal cancer. However, sex-based differences in 5-FU toxicity have yet to be reported in human cancer cell lines and xenograft mouse models to date. Here, we investigated, for the first time, sex-based differences in 5-FU toxicity using human colon cancer cell lines, xenograft mouse models, and Korean patients' data. Female-derived colon cancer cell lines exhibited greater 5-FU-induced cytotoxicity than male-derived colon can...
Source: Biological and Pharmaceutical Bulletin - Category: Drugs & Pharmacology Authors: Tags: Biol Pharm Bull Source Type: research
Conclusions: In summary, per the prespecified study endpoints, eribulin did not have adequate activity in chemotherapy naïve or chemotherapy pretreated patients with metastatic CRPC to support further study in this setting.
Source: American Journal of Clinical Oncology - Category: Cancer & Oncology Tags: Original Articles: Genitourinary Source Type: research
Abstract A vast array of plant-based compounds has enriched red biotechnology to serve the human health and food. A peculiar medicinal plant which was an element of traditional Chinese medicine for centuries as a liver and kidney tonic, for life longevity and hair blackening, is Polygonum multiflorum Thunb. (PM) which is popularly known as "He shou wu" or "Fo-ti" and is rich in chemical components like stilbenes, quinones, and flavonoids which have been used as anti-aging, anti-alopecia, anti-cancer, anti-oxidative, anti-bacterial, anti-hyperlipidemia, anti-atherosclerosis, and immunomodulating...
Source: Applied Microbiology and Biotechnology - Category: Microbiology Authors: Tags: Appl Microbiol Biotechnol Source Type: research
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