Kamada begins Phase II/III Glassia study for treatment of type 1 diabetes
Israel-based Kamada has started a Phase II/III clinical study of its proprietary human Alpha-1 Antitrypsin (AAT) 'Glassia' for the treatment of newly diagnosed paediatric patients with type 1 diabetes (T1D).
Conclusions: GCP patients (otherwise systemically healthy) were characterized by increased Th17-proinflammatory cell phenotype positive for the IL-23 receptor in peripheral blood. The proportion of Th17 cells that are negative for the IL-23 receptor in the peripheral blood of systemically healthy patients seemed to be unaffected by the presence or absence of chronic periodontitis.
CONCLUSIONS: These findings emphasize the concern that psychiatric patients present an altered metabolic profile and that they do not receive adequate treatment for metabolic disruptions. Presence of metabolic disturbances should be routinely assessed, and adequate follow-up is needed to intervene early after illness onset. PMID: 32237298 [PubMed - in process]
Anti‑glycolipid disorder effect of epigallocatechin‑3‑gallate on high‑fat diet and STZ‑induced T2DM in mice. Mol Med Rep. 2020 Mar 26;: Authors: Ren Z, Yang Z, Lu Y, Zhang R, Yang H Abstract Epigallocatechin-3-gallate (EGCG) is beneficial for inhibiting dyslipidemia and reducing hyperlipidemic risk. The purpose of the present study was to investigate the glycolipid regulatory effects and potential mechanisms of EGCG in a high‑fat diet and streptozotocin‑induced type 2 diabetes mellitus (T2DM) mouse model. The results demonstrated that EGCG can decrease blood glucose levels and i...
CONCLUSION: Despite a reduction in the overall burden of depressive symptoms, the migrant subgroup population has a higher probability of presenting these symptoms. Mental health strategies for migrant women are a priority in Peru. PMID: 32237886 [PubMed - in process]
Authors: Huang YM, Shiyanbola OO, Chan HY, Smith PD Abstract Background: Type 2 diabetes (T2D) incurs tremendous health cost associated with various complications due to poor diabetes control. Medication adherence, which is correlated with patients' health literacy, should be consistently practiced achieving optimal diabetes control. A deeper understanding of the specific communication and psychosocial factors related to medication-taking behaviors across different levels of health literacy among people with T2D will guide the development of effective interventions and strategies to enhance medication adherence.Obj...
Conclusions: The home-visit simulation scenario was effective in providing students with a problem-solving experience in conditions similar to reality.Clinical Evidence: Further research is needed to develop various types of community simulation scenarios to enhance competency for community health practice. PMID: 32233948 [PubMed - in process]
Publication date: Available online 2 April 2020Source: Revista Clínica Española (English Edition)Author(s): J.P. Miramontes González, L. Pérez de Isla
Conclusion: Our results suggest that AAT is internalized by β cells through clathrin-mediated endocytosis that leads to the suppression of caspase 9 activation. This process is required for the protective function of AAT in islets when challenged with proinflammatory cytokines or after islet transplantation.
by Ahmed S. Elshikha, Yuanqing Lu, Mong-Jen Chen, Mohammad Akbar, Leilani Zeumer, Andrea Ritter, Hanaa Elghamry, Mahmoud A. Mahdi, Laurence Morel, Sihong Song Systemic lupus erythematosus (SLE) is an autoimmune disorder with a worldwide distribution and considerable mortality and morbidity. Although the pathogenesis of this disease remains elusive, over-reactive dendritic cells (DCs) play a critical role in the disease development. It has been shown that human alpha-1 antitrypsin (hAAT) has protective effects in type 1 diabetes and rheumatoid arthritis mouse models. In the present study, we tested the effect of AAT on DC ...
Question: A 22-year-old man with history of type 1 diabetes mellitus, alpha-1-antitrypsin deficiency (ZZ phenotype), gastroesophageal reflux disease, hyperlipidemia, and depression presented to the hospital for increasing right upper quadrant pain and nausea for 2 weeks. The patient was a former heroin user and an active smoker, but denied significant alcohol use. The patient’s home medications included insulin, atorvastatin, dexlansoprazole, paroxetine, buprenorphine, and trazodone. The patient had poorly controlled diabetes, requiring 6 hospitalizations for diabetic ketoacidosis within the last year.