Team redesigns epilepsy drug to increase potency, specificity, reduce side effects

A more effective version of an FDA-approved epilepsy drug has been designed with the potential for fewer side effects, according to a study. The experimental agent could also prove to be a treatment for tinnitus and other disorders caused by volatile neural signaling.
Source: ScienceDaily Headlines - Category: Science Source Type: news

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AbstractNeurofeedback is a well-investigated treatment for ADHD and epilepsy, especially when restricted to standard protocols such as theta/beta, slow cortical potentials and sensori-motor rhythm neurofeedback. Advances in any field are welcome and other techniques are being pursued. Manufacturers and clinicians are marketing ‘superior’ neurofeedback approaches including 19 channel Z-score neurofeedback (ZNFB) and 3-D LORETA neurofeedback (with or without Z-scores; LNFB). We conducted a review of the empirical literature to determine if such claims were warranted. This review included the above searc...
Source: Applied Psychophysiology and Biofeedback - Category: Psychiatry Source Type: research
Publication date: Available online 11 July 2018Source: American Journal of OtolaryngologyAuthor(s): Helena Wichova, Sameer A. Alvi, James Lin, Keith Sale, Christopher Larsen, Hinrich StaeckerAbstractPurposeVagal nerve stimulation in conjunction with sound therapy has been proposed as a treatment for subjective tinnitus. The purpose of this study is to retrospectively review the effect of VNS on perception of tinnitus in epilepsy patients. We explore the incidence of tinnitus and its perceived reduction in patients requiring implantation of VNS for medically refractory seizures.Materials and methodsA phone survey was conduc...
Source: American Journal of Otolaryngology - Category: Endocrinology Source Type: research
Functional MRI (fMRI) has shown that when you get an uplifting feeling from...Read more on AuntMinnie.comRelated Reading: fMRI offers clues about memory loss in older adults fMRI, machine learning could predict OCD therapy outcomes fMRI shows what makes an angry drunk fMRI, PET could help foresee epileptic seizure issues fMRI helps guide therapy designed to reduce tinnitus
Source: AuntMinnie.com Headlines - Category: Radiology Source Type: news
Progress in drug development has brought a host of novel agents for the treatment of neurological disorders ranging from multiple sclerosis to chronic pain. However, the treatment of most neurological disorders is still dependent on older medications. This includes medications, such as carbamazepine, with clinical activity across a broad number of disorders. Carbamazepine was first approved in 1963 for the treatment of epilepsy but has been used for treating types of schizophrenia, bipolar disorder, neuropathic pain, tinnitus, and trigeminal neuralgia. Although this agent is safe and effective for many patients, there is a...
Source: JAMA Neurology - Category: Neurology Source Type: research
Functional MRI (fMRI) offers clues as to which memory lapses in older adults...Read more on AuntMinnie.comRelated Reading: fMRI, machine learning could predict OCD therapy outcomes fMRI shows what makes an angry drunk fMRI, PET could help foresee epileptic seizure issues fMRI helps guide therapy designed to reduce tinnitus MRI shows brain changes after 1 season of youth football
Source: AuntMinnie.com Headlines - Category: Radiology Source Type: news
By analyzing resting-state functional MRI (fMRI) brain scans with a machine-learning...Read more on AuntMinnie.comRelated Reading: fMRI shows what makes an angry drunk fMRI, PET could help foresee epileptic seizure issues fMRI helps guide therapy designed to reduce tinnitus
Source: AuntMinnie.com Headlines - Category: Radiology Source Type: news
Functional MRI (fMRI) of blood flow in the brain is offering insight into why...Read more on AuntMinnie.comRelated Reading: fMRI, PET could help foresee epileptic seizure issues fMRI helps guide therapy designed to reduce tinnitus
Source: AuntMinnie.com Headlines - Category: Radiology Source Type: news
(Wyss Center for Bio and Neuroengineering) The Wyss Center, a non-profit neurotechnology translation organization, has signed a partnership agreement with German medical engineering company, CorTec. The partners will work together on research, design and development of a device for continuous, long-term, monitoring of the brain's electrophysiological signals for clinical diagnostic and therapeutic applications. The planned device will sit on the skull, beneath the skin and has potential uses in epilepsy monitoring, tinnitus regulation through neurofeedback, neuromodulation for dyslexia and other brain circuit disorders.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
Researchers have developed a method to integrate functional MR (fMRI) and PET...Read more on AuntMinnie.comRelated Reading: PET/MRI outclasses MRI alone for pelvic cancer recurrence fMRI helps guide therapy designed to reduce tinnitus Researchers resolve PET/MRI issue for epilepsy patients PET/MRI could help diagnose kidney transplant infection
Source: AuntMinnie.com Headlines - Category: Radiology Source Type: news
ConclusionsInitial results of DBS studies for diverse neurological disorders are encouraging but larger, controlled, prospective, homogeneous clinical trials are necessary to establish long term safety and effectiveness. The field of neuromodulation continues to evolve and advances in DBS technology, stereotactic techniques, neuroimaging, and DBS programming capabilities are shaping the present and future of DBS research and use in practice.This article is protected by copyright. All rights reserved.
Source: European Journal of Neurology - Category: Neurology Authors: Tags: Reviews Source Type: research
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