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Using smoker's lungs in more transplants 'will save lives despite increased cancer risk for patients'

Doctors argue more patients with terminal illnesses, should be given choice of having ‘reconditioned’ lungs from a smoker, which can give them years of extra life.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news

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Scientists at the Vaccine and Immunotherapy Center (VIC) at Massachusetts General Hospital have uncovered a novel, two-agent immunotherapy combination that worked surprisingly well in animal models with malignant mesothelioma. The discovery has sparked new optimism for immunotherapy, which has struggled to provide consistently positive results with aggressive cancers such as mesothelioma. “This is the beginning of a new story of hope, a new combination of immunotherapy,” Dr. Mark Poznansky, director of the VIC and associate professor at Harvard Medical School, told Asbestos.com. “It worked quite well in a...
Source: Asbestos and Mesothelioma News - Category: Environmental Health Authors: Source Type: news
This study demonstrates that small peptide domains derived from native protein amelogenin can be utilized to construct a mineral layer on damaged human enamel in vitro. Six groups were prepared to carry out remineralization on artificially created lesions on enamel: (1) no treatment, (2) Ca2+ and PO43- only, (3) 1100 ppm fluoride (F), (4) 20 000 ppm F, (5) 1100 ppm F and peptide, and (6) peptide alone. While the 1100 ppm F sample (indicative of common F content of toothpaste for homecare) did not deliver F to the thinly deposited mineral layer, high F test sample (indicative of clinical varnish treatment) formed mainly C...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Authors: Wang Y, Lan GB, Peng FH, Xie XB Abstract Renal transplantation is associated with an increased risk of cancers at multiple sites; however, the relationships between increased cancer risk and participant characteristics remain unclear. We searched PubMed, Embase, and the Cochrane Library to identify prospective observational studies performed up to July 2017. Totally 11 prospective studies reported data on 79,988 renal transplant recipients were included. Renal transplant recipients were found to display a higher risk of all cancers (standard incidence ratio [SIR]: 2.89; 95% CI: 2.13-3.91; P
Source: Oncotarget - Category: Cancer & Oncology Tags: Oncotarget Source Type: research
While journalistic treatment of serious rejuvenation research has improved greatly over the past decade, the mainstream media remains decidedly childish at times. Much of the profession of journalism works hard at producing the appearance of educated folk paid to play the fool, writing for an imagined audience of inattentive, ignorant peers, while ensuring that their education slips through the mask just enough to be seen. It degrades the author and insults the world at large. Everyone in this picture is better than they are portrayed, capable of introspection and self-determination. I noted the article here because it vee...
Source: Fight Aging! - Category: Research Authors: Tags: Daily News Source Type: blogs
(European Association for the Study of the Liver) ILC 2018: HBV DNA integration profile of tumour cells used to guide T cell adoptive immunotherapy in a liver transplant patient with HBsAg-negative HCC metastases in the lungs.
Source: EurekAlert! - Cancer - Category: Cancer & Oncology Source Type: news
This study aimed to evaluate a reader-independent quantitative density metric (QDM) derived from CT histograms to associate with CLAD survival. A retrospective study evaluated CT scans corresponding to CLAD onset using pulmonary function tests in 74 patients (23 RAS, 51 BOS). Two different QDM values (QDM1 and QDM2) were calculated using CT lung density histograms. Calculation of QDM1 includes the extreme edges of the histogram. Calculation of QDM2 includes the central region of the histogram. Kaplan-Meier analysis and Cox regression analysis were used for CLAD prognosis. Higher QDM values were significantly associated wit...
Source: Clinical Lung Cancer - Category: Cancer & Oncology Authors: Tags: Clin Transplant Source Type: research
Authors: Mizdrak M, Džamonja G, Filipović Grčić P Abstract The aim was to evaluate the incidence and characteristics of central nervous system tumors in patients hospitalized at the Department of Neurology, Split University Hospital Centre, during a 10-year period. The study included data on 859 patients with the diagnosis of central nervous system (CNS) tumor. Diagnosis was based on the routine CNS neuroimaging methods (computed tomography/magnetic resonance imaging). Access to patient medical records provided demographic and clinical data, continued by collection of data on potential lethal outcome of patient...
Source: Acta Clinica Croatica - Category: General Medicine Tags: Acta Clin Croat Source Type: research
This study aims to understand the current approach to advanced heart failure patients with active PC .
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Source Type: research
The objectives of the present study are to assess the practice of lung transplant centers regarding the selection of transplant candidates with skin cancer, and a single center outcome of lung transplantation of patients with skin cancer after implementation of ITSCC guideline.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Source Type: research
Pain and stress have been reported after lung transplantation and are likely to jeopardize its result. Supportive care includes a variety of strategies aiming at improving quality of life in sick patients; efficacy has been demonstrated in cancer patients. We started a program of supportive care after lung transplantation. In order to evaluate such a program, we prospectively analysed the effect of massage therapy on pain, mood and vital signs.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Source Type: research
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