Prednisolone, Indomethacin Similarly Effective for Acute Gout

Oral prednisolone is as effective as indomethacin for relieving pain in acute gout and should be considered a first-line treatment option, according to a report published online in Annals of Internal Medicine.
Source: Caring for the Ages - Category: Health Management Authors: Source Type: news

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Conclusions: Collectively, our findings indicated that Cyr61 was highly expressed in rat models of gout. By inhibiting the expression of Cyr61, Huzhang Tongfeng granule could partially attenuate the inflammation induced by MSU crystal. PMID: 32419834 [PubMed]
Source: Evidence-based Complementary and Alternative Medicine - Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research
An 80 year old male presented to the emergency department after an episode of gross hematuria four hours prior. Review of systems at the emergency department was positive for dysuria and chronic obstructive urinary symptoms while negative for fevers, chills, or flank pain. Of note, his past medical history includes atrial fibrillation on rivaroxaban anticoagulation, left bundle branch block, coronary artery disease (status post drug eluting stent placement to the left circumflex artery in 2003 and drug eluting stent placement to the left anterior descending artery in 2013), peripheral vascular disease (status post bilatera...
Source: Urology - Category: Urology & Nephrology Authors: Tags: Grand Rounds Source Type: research
Rationale: Intraspinal tophaceous gout is relatively rare condition presenting with major clinical manifestations, such as spinal cord or nerve roots compressions (radiculopathy). It is usually difficult to differentiate intraspinal tophaceous gout, lumbar disc herniation, stenosis of spinal canal, ossification of ligamentum flavum, and other degenerative spinal disorders from each other. Patient concerns: A 64-year-old man was admitted with a history of progressive low back pain for 11 months. He also presented with radiculopathy and numbness of his left lower extremity. Diagnoses: Preoperative computed tomography...
Source: Medicine - Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research
(Natural News) Arthritis refers to a group of degenerative conditions that target the joints and the tissues that surround the joints. Common types of arthritis include osteoarthritis, rheumatoid arthritis and gout. Although each type is influenced by unique factors, arthritis is generally characterized by pain, stiffness and inflammation in the hands, hips and knees. Medicinal herbs,...
Source: NaturalNews.com - Category: Consumer Health News Source Type: news
CONCLUSIONS: The long-term standard treat-to-target ULT strategy benefits patients for both gout-related issues and their extra-articular organs. The current study suggests that there is a better chance to achieve the rates of adherence to ULT and the target of sUA levels in the setting of a dedicated gout clinic. PMID: 32444582 [PubMed - as supplied by publisher]
Source: Technology and Health Care - Category: Medical Devices Authors: Tags: Technol Health Care Source Type: research
In this study, the activity of 1-palmitoyl-2-linoleoyl-3-acetyl-rac-glycerol (PLAG) in attenuation of excess neutrophil infiltration was assessed in gout-induced lesions of BALB/c mice. Neutrophil infiltration in MSU-induced gouty lesions was analyzed using immunohistochemical staining. ELISA and RT-PCR were used to measure attenuation of expression of the major neutrophil chemoattractant, CXC motif chemokine ligand 8 (CXCL8), in a PLAG-treated animal model and in cells in vitro. The animal model revealed massive increased neutrophil infiltration in the MSU-induced gouty lesions, but the PLAG-treated mice had significantly...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
ConclusionsMSU-induced gout pain may be related to the hyperexcitability of DRG neurons elicited by decreasing K+ currents.
Source: Inflammation Research - Category: Research Source Type: research
‚ÄčThe wrist is not commonly aspirated in the emergency department, but emergent arthrocentesis may be indicated for extreme or concerning cases, and tapping the wrist to determine the underlying pathology or relieve pain may be of great value. The synovial fluid from the joint space can be analyzed for crystals, infection, and blood. This information may help determine the overall plan and aid in decision-making and consultation. The ultimate treatment plan may include admission, intravenous antibiotics, multiple aspirations, and even surgical washout.A swollen, painful wrist that is hot to the touch is concerning for sep...
Source: The Procedural Pause - Category: Emergency Medicine Tags: Blog Posts Source Type: blogs
Over the course of three days, intense pain, redness and swelling of the left fifth toe wrought great havoc to a 67-year-old man [Figure 1]. There was no antecedent trauma, insect bite, nor change in medication. He denied fever, chills or walking barefoot. He had known hypertension and vitamin D deficiency. As a child, he was diagnosed with psoriasis; skin lesions intermittently recurred into adulthood. Both his parents had gout and a grandfather had psoriasis.
Source: The American Journal of Medicine - Category: General Medicine Authors: Tags: DIAGNOSTIC DILEMMA Source Type: research
A 67-year-old man presented with 3 days of intense pain, redness, and swelling of the left fifth toe, which had been extremely troubling (Figure 1). There was no antecedent trauma, insect bite, or change in medication. He denied fever, chills or walking barefoot. He had known hypertension and vitamin D deficiency. As a child, he was diagnosed with psoriasis; skin lesions intermittently recurred into adulthood. Both his parents had gout and a grandfather had psoriasis.
Source: The American Journal of Medicine - Category: General Medicine Authors: Tags: DIAGNOSTIC DILEMMA Source Type: research
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