Klinefelter syndrome 47,XXY - Male Breast...

Klinefelter syndrome is a rare genetic condition in which a man has an extra X chromosome. (Males usually have one X and one Y chromosome.) Some of the other conditions associated with Klinefelter are hypothyroidism, infertility, testicular cancer, and an increased risk for male breast cancer.
Source: About.com Breast Cancer - Category: Cancer & Oncology Authors: Tags: health Source Type: news

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Dr John Baillie, Professor Emeritus at Virginia Commonwealth University (VCU) Health System, passed away peacefully on October 29, 2018, after a battle with brain cancer. He was at his home in Durham, North Carolina, surrounded by his wife, Alison, their children, Katie and Chris, and their dogs, Lucy and Dougal. And he wouldn't have wanted it any other way!
Source: Gastrointestinal Endoscopy - Category: Gastroenterology Authors: Tags: In memoriam Source Type: research
Duodenal carcinoma is a rare manifestation of familial adenomatous polyposis (FAP). A lifetime cumulative incidence of duodenal cancer of around 4.5% (95% confidence interval, 0.1%-8.9%) was reported by the age of 57 years in the period of 1990 to 2001.1 In the meantime, however, the improved treatment of patients with FAP in general has resulted in longer life expectancy.2 Therefore, the natural course of the disease progresses further, and patients experience more-advanced stages of duodenal polyposis.
Source: Gastrointestinal Endoscopy - Category: Gastroenterology Authors: Tags: Original article Source Type: research
Authors: Bang CS, Baik GH Abstract Endoscopic submucosal dissection (ESD) is a standard treatment for patients with gastrointestinal neoplasms with a negligible risk of lymph node metastasis. ESD enables en bloc resection of gastrointestinal neoplasms and organ preservation, thereby, avoiding surgical treatment. Although small (
Source: Clinical Endoscopy - Category: Gastroenterology Tags: Clin Endosc Source Type: research
Authors: Dousset L, Boniface K, Seneschal J Abstract Antibody-based therapeutics targeting programmed cell death 1 (PD-1) have shown strong efficacy in the treatment of metastatic cancers as melanoma. However, restoring the immune function with these therapies to target cancer cells leads to immune side effects including immune cutaneous events. Vitiligo-like lesions in patients receiving anti-PD-1 is one of the most common skin adverse event reported and the incidence seems to be higher than in patients receiving other immune-checkpoints therapies. Initially described in patients with metastatic melanoma, vitiligo...
Source: Giornale Italiano di Dermatologia e Venereologia - Category: Dermatology Tags: G Ital Dermatol Venereol Source Type: research
This study sought to test a methodology for estimating over-screening due to excessive periodicity, defined as a smaller than recommended interval between exams, and its association with socio-demographic characteristics. A cohort of women who underwent mammography in 2010, and whose result was normal, was assembled through probabilistic linkage SISMAMA records based on a set of personal identifiers. We used data from women living in the micro health region of Juiz de Fora/Lima Duarte/Bom Jardim, Minas Gerais State, Brazil, who were followed in the System until the end of 2012. The rate of over-screening was 150/1,000 wome...
Source: Cadernos de Saude Publica - Category: International Medicine & Public Health Authors: Tags: Cad Saude Publica Source Type: research
a RAG Abstract PMID: 30652819 [PubMed - in process]
Source: Cadernos de Saude Publica - Category: International Medicine & Public Health Authors: Tags: Cad Saude Publica Source Type: research
(Ulsan National Institute of Science and Technology(UNIST)) Jun Ho Lee, a doctroral student in Life Sciences at South Korea's Ulsan National Institute of Science and Technology (UNIST), named a recipient of 2018 Life Science Awards.
Source: EurekAlert! - Cancer - Category: Cancer & Oncology Source Type: news
Patients with advancing illness have one or more serious conditions (like cancer, congestive heart failure, or dementia, for example) and are experiencing symptoms that impact their quality of life and activities of daily living. In addition, they may be having side effects from treatments, problems eating, frequent emergency department visits, or hospitals readmissions. They may be in an end-of-life stage and could be receiving palliative or hospice care. They rely heavily on paid and unpaid caregivers.        
Source: The Commonwealth Fund: Publications - Category: International Medicine & Public Health Authors: Source Type: research
CONCLUSIONS TCL-based immunotherapy has discrepant anti-tumor efficiency in different TNBC cell lines by PDL-1/PD interaction, providing the theoretical basis of TCL-based immunotherapy in TNBC. PMID: 30653481 [PubMed - in process]
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
This study aimed to investigate the effects of metastasis-associated 1 (MTA1) gene expression and gene silencing in human non-small cell lung cancer (NSCLC) cells in vitro and on angiogenesis in tumor xenografts in vivo in nude mice. MATERIAL AND METHODS Human H460 and H1299 NSCLC cell lines underwent transfection with lentiviral transfer plasmids (lenti) and short-interfering RNA (si-RNA) and included a control group, a lenti-MTA1 group, a lenti-si-MTA1 group, a lenti control group, and a si-RNA control group. Quantitative reverse transcription polymerase chain reaction (qRT-PCR) was used to detect MTA1 gene expression af...
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
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