Crystal Induced Nephrotoxicity Associated with Acyclovir Use in Paediatric Patient

Publication date: Available online 26 March 2016 Source:Pediatric Infectious Disease Author(s): Abin Chandrakumar, Pretty G Tharakan, Bittu Thomas, Anu Albert, Teena Jacob Drug induced nephrotoxicity has evolved as one of the significant causes of renal failure in the contemporary setting accounting up to 20%. Acyclovir is an antiviral agent which has potential for precipitating transient crystal induced nephrotoxicity especially in elderly, euvolemic or renal patients when given as rapid intravenous bolus. The current case depicts evolution and management of transient nephropathy in a paediatric patient treated with Acyclovir for viral encephalopathy. The case presents a contrasting scenario to the conventional milieu of risk factors and surmise the possibility of genetic factor predisposition.
Source: Pediatric Infectious Disease - Category: Pediatrics Source Type: research