Alcohol Hits You When It Is Hard: Intoxication, Task Difficulty, and Theta Brain Oscillations.

CONCLUSIONS: The spatiotemporal theta profile across the 2 tasks supports the concept of a rostrocaudal activity gradient in the medial prefrontal cortex that is modulated by task difficulty, with the dAC as the key node in the network subserving cognitive control. Conflict-related theta power was selectively reduced by alcohol only under the more difficult task which is indicative of the alcohol-induced impairment of conflict monitoring and top-down regulation. Compromised executive control under alcohol may underlie a range of adverse effects including reduced competency in conflict-inducing or complex situations. PMID: 27012442 [PubMed - as supplied by publisher]
Source: Alcoholism, Clinical and Experimental Research - Category: Addiction Authors: Tags: Alcohol Clin Exp Res Source Type: research

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Molecules, Vol. 26, Pages 5824: Exploring the Dual Characteristics of CH3OH Adsorption to Metal Atomic Structures on Si (111)-7 × 7 Surface Molecules doi: 10.3390/molecules26195824 Authors: Wenxin Li Jiawen Wang Wanyu Ding Youping Gong Huipeng Chen Dongying Ju Metal atoms were deposited on an Si (111)-7 × 7 surface, and they were adsorbed with alcohol gases (CH3OH/C2H5OH/C3H7OH). Initially, CnH2n+1OH adsorption was simply used as an intermediate layer to prevent the chemical reaction between metal and Si atoms. Through scanning tunneling microscopy (STM) and a mass spectrometer, the CnH2n+1OH ...
Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research
This study set out to assess for any such associations.Materials and methodsA retrospective review was completed of consecutive patients that had CTA neck imaging prior to CEA. Body mass index (BMI), tobacco and/or alcohol use, and history of diabetes and/or hypertension were collected from patients ’ medical records. Lab values were dichotomized based on values: total cholesterol
Source: Neuroradiology - Category: Radiology Source Type: research
Source: Reuters: Health - Category: Consumer Health News Source Type: news
Green Chem., 2021, Accepted Manuscript DOI: 10.1039/D1GC02807C, CommunicationJianyang Dong, Fuyang Yue, Jianhua Liu, Hongjian Song, Yu-Xiu Liu, Qingmin Wang Methods for heteroarylethyl alcohol synthesis are critical to the chemical and pharmaceutical industries. Herein, we report a mild, modular, practical Minisci reaction for catalytic synthesis of heteroarylethyl alcohols via sequential... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Green Chem. latest articles - Category: Chemistry Authors: Source Type: research
Neuropharmacology. 2021 Sep 22:108807. doi: 10.1016/j.neuropharm.2021.108807. Online ahead of print.ABSTRACTInteroception refers to the perception of the internal state of the body and is increasingly being recognized as an important factor in mental health disorders. Drugs of abuse produce powerful interoceptive states that are upstream of behavior that drive and influence intake, and addiction pathology is impacted by interoceptive processes. The goal of the present review is to discuss interoceptive processes related to alcohol. We will cover physiological responses to alcohol, how interoceptive states can impact drinki...
Source: Neuropharmacology - Category: Drugs & Pharmacology Authors: Source Type: research
In this study, we developed a DSF-LF nanoparticulate system (DSF-LF NP) for combining the immunosuppressive activities of both DSF and LF. DSF-LF NPs could effectively block pyroptosis and inflammatory cytokine release from macrophages. Treatment with DSF-LF NPs showed remarkable therapeutic effects on lipopolysaccharide (LPS)-induced sepsis. In addition, this therapeutic strategy was also applied to treat ulcerative colitis (UC), and substantial treatment efficacy was achieved in a murine colitis model. The underlying mode of action of these DSF-LF-NPs may contribute to efficiently suppressing macrophage-mediated inflamma...
Source: Acta Pharmacologica Sinica - Category: Drugs & Pharmacology Authors: Source Type: research
Environ Sci Pollut Res Int. 2021 Sep 24. doi: 10.1007/s11356-021-16506-6. Online ahead of print.ABSTRACTCurrently, the world faces difficulties related to the quantity and quality of water because of industrial expansion, population growth, and urbanization intensification. Biosorption is considered a promising technology that can be applied to remove toxic metals (TMs) and rare-earth metals (REMs) in wastewater at low concentrations, due to its efficiency and low cost. In this work, we investigated different non-conventional biosorbents to remove metallic ions (TMs and REMs) in biosorptive affinity tests. Metallic affinit...
Source: Environmental Science and Pollution Research International - Category: Environmental Health Authors: Source Type: research
This study investigated the relationships among genetic variants of the MMP-2, MMP-9, TIMP-1, and TIMP-2 genes and AD.METHODS: Two hundred and thirteen probable AD patients and 315 control participants of the Tai- wan population were recruited for primary investigations, and we used the data of 763 participants from the Taiwan Biobank (TWB), as controls, for validation. Multivariable logistic regression was performed with adjustments for age, sex, hypertension, diabetes mellitus (DM), and alcohol con- sumption. The associations between the genotypes and allele frequencies and the SNP-associated AD hereditary models were an...
Source: Current Alzheimer Research - Category: Neurology Authors: Source Type: research
Contributors : Alex M DePaoli ; Stephen A Harrison ; Mei Zhou ; Daniel D Kaplan ; James F Trotter ; Angelo H Paredes ; Steven C Hunt ; Ted D Adams ; Marc Learned ; Hui Tian ; Stephen J Rossi ; Lei LingSeries Type : Expression profiling by arrayOrganism : Rattus norvegicusGastric bypass surgery has proven to be the most effective treatment in controlling hyperglycemia in severely obese patients with diabetes. Here we show that FGF19, a gut hormone, is rapidly induced by bypass surgery in rodents and humans. Administration of FGF19 achieves remission of diabetes through mechanisms beyond weight loss in animal models of diabe...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by array Rattus norvegicus Source Type: research
HIGH cholesterol is when you have too much of a fatty substance called cholesterol in your blood. It is mainly caused by eating fatty food, not exercising enough, being overweight, smoking and drinking alcohol. Rosuvastatin is often prescribed to treat high cholesterol as well as to prevent heart disease.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
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