Four new phorbol diesters from Croton tiglium and their cytotoxic activities

Publication date: June 2016 Source:Phytochemistry Letters, Volume 16 Author(s): Xiao-Long Zhang, Ashfaq-Ahmad Khan, Lun Wang, Kai Yu, Fu Li, Ming-Kui Wang Phytochemical investigation of the seeds of Croton tiglium resulted in the isolation and structure elucidation of four new 4-deoxy-4β-phorbol diesters (1–4) named as 12-O-tiglylphorbol-4-deoxy-4β-phorbol-13-acetate (1), 12-O-tiglylphorbol-4-deoxy-4β-phorbol-13-hexadecanoate (2), 13-O-acetylphorbol-4-deoxy-4β-phorbol-20-oleate (3) and 13-O-acetylphorbol-4-deoxy-4β-phorbol-20-linoleate (4), respectively. The structures of the new compounds were established by 1D, 2D-NMR and HR-ESI–MS spectroscopic data and chemical degradation experiments. The cytotoxic activities of compounds 1–4 were evaluated against hepatic tumor cell lines (SNU387 and SNU398). Among these compounds, compound 4 exhibited the most potent activity against the SNU387 with IC50 value of 0.71μM. Graphical abstract

Source: Phytochemistry Letters - March 25, 2016 Category: Chemistry Source Type: research