Lyme: Fight Harder For Science and End This War

I just had a flashback. When I was diagnosed with Lyme, I knew little about it. I went to the first infectious disease doctor with my bullseye still present, asking lots of questions. Among them, are you sure this three weeks of doxycycline is enough. He smiled, and with his eyes fixed on his computer, he said, "Yes, it's more than enough. In fact, I could just tell you to take ten days but then you'd come back later if anything went haywire and ask why I didn't give you twenty-one." He looked up, "Call me if anything goes crazy." A month later, I called. I woke up with a very sore throat and fever two days before my brother's wedding and a gland in my neck that felt like a pulsating grape. It was movable but scarily large. He said if it didn't go down in a few weeks, to let him know. It didn't, so I called again. He thought I should have it biopsied. I thought I should go see my ear, nose and throat doctor instead, who sent me for an ultrasound but felt it was a remnant of Lyme. The radiologist said it was big, but symmetrical, and not particularly alarming. He also found a few more and said to have my neck rescanned in three months. I want to point out that this symptom is extremely typical of a Lyme co-infection called Bartonella, which of course, I did not know at the time. Is that what the ID doc meant when he said to reach out if anything went crazy? He seemed more than willing to have me get a biopsy of a lymph node that sits on top of my carotid a...
Source: Science - The Huffington Post - Category: Science Source Type: news

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Publication date: Available online 14 October 2019Source: Food ChemistryAuthor(s): Jianghao Sun, Craig S. Charron, Janet A. Novotny, Bing Peng, Liangli Yu, Pei ChenAbstractBroccoli is a popular brassica vegetable and its consumption may decrease the occurrence of cancer in certain populations. To gain insight into the metabolites that may induce physiological responses to broccoli intake, a non-targeted metabolomic approach and a targeted approach for analysis of glucosinolate metabolites were developed using high resolution accurate mass spectrometry. A human study was conducted in which 6 subjects consumed a single meal ...
Source: Food Chemistry - Category: Food Science Source Type: research
Publication date: Available online 13 October 2019Source: Advances in Biological RegulationAuthor(s): Veronica Balatti, Carlo M. CroceAbstractWe established that loss of miR-15a/16–1 genes on chromosome 13q14 is the most common alteration in Chronic Lymphocytic Leukemia (CLL) and that miR-15/16 are crucial negative regulator of BCL-2, an antiapoptotic gene overexpressed in most CLLs and in many other malignancies. We have also shown that miR-15/16 target ROR1, a cell surface receptor for Wnt5a which can enhance growth/survival of CLL cells. Interestingly, ROR1 is expressed by many cancers, but not by normal adult tis...
Source: Advances in Biological Regulation - Category: Biology Source Type: research
Publication date: 1 December 2019Source: Colloids and Surfaces B: Biointerfaces, Volume 184Author(s): Maosheng Xu, Kunsong Zhang, Yubing Liu, Jie Wang, Ke Wang, Yuanqing ZhangAbstractThe treatment of cancer has always been a worldwide problem. The combination of chemotherapy and other therapies would be a promising therapy strategy. Photothermal therapy (PTT) does not cause serious side effects and has dual control of time and space, which was considered to be a good method for combination with chemotherapy. Here, we modified multifunctional nanosheets based on in-situ gold nanoparticles (Au NPs) grown molybdenum disulfide...
Source: Colloids and Surfaces B: Biointerfaces - Category: Biochemistry Source Type: research
Publication date: Available online 13 October 2019Source: Sensors and Actuators B: ChemicalAuthor(s): Chaonan Yang, Qingfu Guo, Yan Lu, Bin Zhang, Guangming NieABSTRACTA novel “signal-on” electrochemiluminescence (ECL) immunosensor is constructed by using Au nanoparticle/graphene quantum dots-poly(etherimide)-graphene oxide (AuNP/GQDs-PEI-GO) composite as a probe to detect prostate-specific antigen (PSA). GQDs and AuNP are modified onto the PEI-GO through amide bond and electrostatic interaction sequentially. Poly(indole-6-carboxylic acid)/flower-like Au nanoparticles (PICA/FGNs) composites with satisfactory co...
Source: Sensors and Actuators B: Chemical - Category: Chemistry Source Type: research
Publication date: Available online 13 October 2019Source: Colloids and Surfaces A: Physicochemical and Engineering AspectsAuthor(s): Cleverson J.F. Oliveira, Sunny K.S. Freitas, Igor Guida P.P de Sousa, Pierre M. Esteves, Renata A. SimaoAbstractThe present study reports the formation of thin films from covalent organic framework (COF) via ultrasound using different solvents. The morphology of the resulting films was correlated to the rate of bubble formation and the maximum bubble size, through derivations from the Rayleigh-Plesset equation. Solvents were chosen according to their different characteristics, such as polariz...
Source: Colloids and Surfaces A: Physicochemical and Engineering Aspects - Category: Chemistry Source Type: research
Publication date: Available online 14 October 2019Source: Chemical Engineering JournalAuthor(s): Yang-Rui Huang, Huai-Zheng Li, Xin-Min Wei, Deng-Hui Wang, Yu-Ting Liu, Lei LiAbstractThe effect of low frequency ultrasonic treatment on the growth of cyanobacteria and the behavior of extracellular organic matter (EOM) were investigated in this study. The growth of cyanobacteria can be controlled effectively by low frequency ultrasonic treatment, and the inhibitory effect of ultrasound on the photosynthetic ability of cells was more significant than on the cells density (the minimum values of cells density and chlorophyll-a w...
Source: Chemical Engineering Journal - Category: Chemistry Source Type: research
Publication date: Available online 13 October 2019Source: Journal of Photochemistry and Photobiology B: BiologyAuthor(s): Kubra Bilici, Abdullah Muti, Alphan Sennaroğlu, Havva Yagci AcarAbstractSuperparamagnetic iron oxide nanoparticles (SPIONs) have been recently recognized as highly efficient photothermal therapy (PTT) agents. Here, we demonstrate, for the first time to our knowledge, dose and laser intensity dependent PTT potential of small, spherical, 3-aminopropyltrimethoxysilane coated cationic superparamagnetic iron oxide nanoparticles (APTMS@SPIONs) in aqueous solutions upon irradiation at 795 nm. Indocyanine gr...
Source: Journal of Photochemistry and Photobiology B: Biology - Category: Speech-Language Pathology Source Type: research
It will have a fully staffed emergency room, about 10 observation beds plus, in Hempfield's case, an AHN cancer center and other physician offices.
Source: bizjournals.com Health Care:Biotechnology headlines - Category: Biotechnology Authors: Source Type: news
This study intended to compare the benefits of 2 mind-body interventions-yoga and mindfulness-in a hospital setting. Design: The research team performed a retrospective analysis of outcome data obtained from a hospital's programs. Setting: The study took place at a mind-body center at a hospital in Athens, GA (USA). Participants: Participants were 46 individuals enrolled either in a yoga (n = 24) or a mindfulness (n = 22) intervention program at the hospital. Intervention: Participants self-selected a mind-body-intervention program offered at the hospital: yoga or mindfulness. They received guided training ...
Source: Advances in Mind Body Medicine - Category: Psychiatry Tags: Adv Mind Body Med Source Type: research
Abstract Next-generation sequencing of DNA and RNA obtained from liquid biopsies of cancer patients may reveal important insights into disease progression and metastasis formation, and it holds the promise to enable new methods for noninvasive screening and clinical decision support. However, implementing liquid biopsy sequencing protocols is challenged by capturing circulating tumor cells or cell-free tumor DNA from blood samples, by amplifying genomic DNA and RNA in a reliable and unbiased manner, and by extracting biologically meaningful signals from the noisy sequencing data. In this chapter, we discuss comput...
Source: Cell Research - Category: Cytology Authors: Tags: Recent Results Cancer Res Source Type: research
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