Extracting genetic alteration information for personalized cancer therapy from ClinicalTrials.gov

Discussion: The automated cancer treatment trial identification system achieved a high precision of 0.9944. Together with the manual review process, it identified 20 193 cancer treatment trials from ClinicalTrials.gov. The automated gene-alteration extraction system achieved a precision of 0.8300 and a recall of 0.6803. After validation by manual review, we generated a knowledge base of 2024 cancer trials that are labeled with specific genetic alteration information. Analysis of the knowledge base revealed the trend of increased use of targeted therapy for cancer, as well as top frequent gene-alteration pairs of interest. We expect this knowledge base to be a valuable resource for physicians and patients who are seeking information about personalized cancer therapy.

Source: Journal of the American Medical Informatics Association - March 23, 2016 Category: Information Technology Authors: Xu, J., Lee, H.-J., Zeng, J., Wu, Y., Zhang, Y., Huang, L.-C., Johnson, A., Holla, V., Bailey, A. M., Cohen, T., Meric-Bernstam, F., Bernstam, E. V., Xu, H. Tags: Research and Applications Source Type: research