Relaxin deficiency results in increased expression of angiogenesis- and remodelling-related genes in the uterus of early pregnant mice but does not affect endometrial angiogenesis prior to implantation.

CONCLUSIONS: Relaxin treatment modulates expression of a variety of angiogenesis-related genes in HES cells. However, despite accelerated uterine gene expression of steroid receptor, progesterone and angiogenesis and extracellular matrix remodeling genes in Rln-/- mice, there was no impact on angiogenesis. We conclude that although relaxin deficiency results in phenotypic changes in the pre-implantation uterus, endogenous relaxin does not play a major role in pre-implantation angiogenesis in the mouse uterus. PMID: 27005936 [PubMed - in process]

http://www.ncbi.nlm.nih.gov/pubmed/27005936?dopt=Abstract

Source: Reproductive Biology - March 25, 2016 Category: Reproduction Medicine Authors: Marshall SA, Ng L, Unemori EN, Girling JE, Parry LJ Tags: Reprod Biol Endocrinol Source Type: research