This Disease Can Still Get You Quarantined For Months -- And It's On The Rise

In August 2014, Kate O’Brien, a 34-year-old media producer from Brooklyn, found out she was expecting her second child. She was ecstatic. But this pregnancy didn't proceed like the first. For the next few months, O'Brien had a cold she couldn't shake. She woke up in the middle of the night drenched in sweat. She wanted to blame it on her pregnancy, yet she kept losing weight. She could barely eat. She coughed up balls of bloody mucus. Her throat burned. None of her doctors could figure out what was wrong. A physician sent her to Mount Sinai West Hospital in Manhattan in January 2015, when, at five months pregnant, she still couldn't gain any weight. "No one likes a skinny pregnant lady," she said. O'Brien expected to stay at the hospital overnight. She didn’t get a chance to say goodbye to her 2-year-old, Donny, but she figured she'd be home soon. She didn't walk out of the hospital for 75 days. @media (max-width: 499px) { .desktop { display: none; } } @media (min-width: 500px) { .mobile { display: none; } } The doctors at Mount Sinai diagnosed O'Brien with infectious tuberculosis. After a few days in the intensive care unit, she was shifted to a negative-pressure isolation room, which helps contain the infected air. Signs announcing "WARNING: Infectious Disease" were affixed to the room's airtight set of double doors. And all O'Brien could think about was what this meant for her unborn baby. The federal policy that governs medical isol...
Source: Science - The Huffington Post - Category: Science Source Type: news

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ConclusionsSurvey-based vaccination data may under- or over-estimate coverage, but most adults require at least one additional vaccination by any metric. A composite measure provides a single focal point to promote adherence to standards of care.
Source: American Journal of Preventive Medicine - Category: International Medicine & Public Health Source Type: research
We report a successful case of hepatic ductoplasty combined with hepaticojejunostomy (H-J) for the treatment of iatrogenic Bismuth type 2 stricture.Presentation of caseThe patient was a 68-year-woman who had undergone choledochojejunostomy (C-J) 6 years earlier due to bile duct injury after laparoscopic cholecystectomy for cholelithiasis. She complained of recurrent chills and upper back pain. Cholangiography and computed tomography revealed a C-J anastomotic stricture with hepatolithiasis. The diagnosis was reflux cholangitis with hepatolithiasis due to C-J stricture and a fistula between the reconstructed jejunal limb an...
Source: International Journal of Surgery Case Reports - Category: Surgery Source Type: research
Abstract Natural medicinal substances (NMS) have great inconsistency due to chemical variability, seriously limiting their development as therapeutics. Here, we chose toad venom with anti-tumor activities as a model and developed a pipeline of metabolomics-based screening and quality consistency control (MSQCC) as one potential solution to this long-standing problem. Our study firstly exemplified the power of the co-correlation screen of metabolomic and biological profiles of 180 fractions prepared from natural heterogeneous venom samples, to identify a series of bufadinolides as quality control markers for cancer...
Source: Analytica Chimica Acta - Category: Chemistry Authors: Tags: Anal Chim Acta Source Type: research
Source: BMJ Comments - Category: General Medicine Source Type: forums
Publication date: Available online 19 August 2018Source: International Journal of PharmaceuticsAuthor(s): Christoffer von Halling Laier, Blake Gibson, Marco van de Weert, Ben J. Boyd, Thomas Rades, Anja Boisen, Sarah Hook, Line Hagner NielsenAbstractSubunit vaccine formulations are often produced as liquid dispersions through complicated processes. It is desirable, however, to have simple, cheap and up-scalable methods to produce nanoparticulate subunit vaccines in powder form. Here, a simple single-step spray drying process for production of powder cubosome precursors with the model antigen ovalbumin (OVA) and the adjuvan...
Source: International Journal of Pharmaceutics - Category: Drugs & Pharmacology Source Type: research
Paeoniflorin inhibits IL-1β-induced MMP secretion via the NF-κB pathway in chondrocytes. Exp Ther Med. 2018 Aug;16(2):1513-1519 Authors: Hu PF, Sun FF, Jiang LF, Bao JP, Wu LD Abstract Paeoniflorin serves important cellular roles, exerting anti-cancer, anti-inflammatory and anti-pulmonary fibrosis effects and possesses immune-modulatory properties. However, the exact role of paeoniflorin in the pathogenesis of osteoarthritis (OA) remains unclear. The aim of the present study was to investigate the effects of paeoniflorin on articular surfaces in vitro. Rat chondrocytes were cultured in vitro...
Source: Experimental and Therapeutic Medicine - Category: General Medicine Tags: Exp Ther Med Source Type: research
Authors: Zhang M, Liu J, Li M, Zhang S, Lu Y, Liang Y, Zhao K, Li Y Abstract Glioblastoma multiforme (GBM) is a malignant tumor caused by complex pathological mechanisms, and is characterized by a high rate of cancer-related mortality and poor patient prognosis. Overgrowth of cancer cells, which results from the inhibition of cell apoptosis and/or the promotion of cell proliferation, leads to the progression of GBM. Therefore, studies into the regulatory mechanisms of cancer cell growth in GBM are required to identify potential therapeutic targets and improve treatment for GBM. In the present study, the role of ins...
Source: Experimental and Therapeutic Medicine - Category: General Medicine Tags: Exp Ther Med Source Type: research
Authors: Zhang X, Chen L Abstract Renal cell carcinoma (RCC) and chronic kidney disease (CKD) are associated with hypoxia, but the effects of hypoxia on the process of angiogenesis in the two diseases are dramatically different. Some of matrix metalloproteinases (MMPs), such as MMP2 and MMP9, may have a role because they represent the most prominent family of proteinases associated with angiogenesis. In the present study, the differential response of human renal cell cancer cells (786-0), human renal tubular epithelial cells (HK-2) and human microvascular endothelial cells (HMEC-1) to hypoxia with regards to the ex...
Source: Experimental and Therapeutic Medicine - Category: General Medicine Tags: Exp Ther Med Source Type: research
Authors: Zuo Q, Gao F, Song H, Zhou J Abstract The aim of the present study is to investigate the clinical value of Ilizarov transverse tibial bone transport and microcirculation reconstruction in the treatment of chronic ischemic diseases in lower limbs. A total of 90 patients with chronic ischemic diseases in lower limbs were selected and randomly divided into two groups: The observation group (n=45) and the control group (n=45). Those patients were treated with Ilizarov transverse tibial bone transport and microcirculation reconstruction, and percutaneous balloon angioplasty (PTBA), respectively. Changes in the ...
Source: Experimental and Therapeutic Medicine - Category: General Medicine Tags: Exp Ther Med Source Type: research
Authors: Lee SY, Lim S, Cho DH Abstract A 16-year-old female with Ewing sarcoma, a very rare disease with poor prognosis in women, was admitted to the hospital with abdominal pain. Diagnostic laparotomy revealed the Ewing sarcoma originating from the extramural uterus. Histological examination yielded positive test results for CD99, vimentin, S-100, eosin 5-maleimide and periodic acid-Shiff. EWS-FLI1 type 1 translocation was confirmed. Fibroblast growth factor receptor (FGFR) 4 (c.1162G> A) and HRas proto-oncogene (HRAS; c.182A> G) mutations were also detected. At eight months following complete remission, pe...
Source: Experimental and Therapeutic Medicine - Category: General Medicine Tags: Exp Ther Med Source Type: research
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