Changes in reduced glutathione, oxidized glutathione, and glutathione peroxidase in cats with naturally occurring chronic kidney disease

The objective of this study was to determine oxidative stress in CKD cats by measuring changes in reduced glutathione (GSH), oxidized glutathione (GSSG), glutathione peroxidase (GPx), and reduced glutathione to oxidized glutathione (GSH/GSSG) ratio in cats with naturally occurring chronic kidney disease (CKD). Thirteen clinically normal client-owned aged-matched cats and 23 naturally occurring CKD cats were included. Completed blood count, blood urea nitrogen, creatinine, GSH, GPx, GSSG, and GSH/GSSG ratio were measured on the first day of diagnosis. The results showed that CKD cats had significantly lower GSH, GPx, and GSH/GSSG ratio levels (2.77 ± 0.27 mM, 2.32 ± 0.40 nmol/min and 148.26 ± 34.19) than the clinically normal client-owned age-matched cats (4.23 ± 0.67 mM, 6.68 ± 0.79 nmol/min and 312.64 ± 76.80). The GSSG in the CKD cats (35.20 ± 4.37 μM) was significantly higher than in the clinically normal client-owned age-matched cats (19.66 ± 2.75 μM). The results indicated that cats with naturally occurring CKD experience oxidative stress.
Source: Comparative Clinical Pathology - Category: Pathology Source Type: research

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Authors: Boateng JO, Boafo N, Osafo C, Anim-Sampong S Abstract Background: Chronic kidney disease is a major public health challenge, globally. Inadequate excretion of metabolic waste products by the kidneys results in circulation of these toxic materials in the body. This can cause damage to tissues and organ systems including the auditory system which can lead to hearing loss. Aim: The study was aimed at determining the prevalence, degrees and types of hearing impairment among Chronic kidney disease patients on haemodialysis in Ghana. Methods: A case-control study involving 50 Chronic Kidney disease patie...
Source: Ghana Medical Journal - Category: African Health Tags: Ghana Med J Source Type: research
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Source: Ghana Medical Journal - Category: African Health Tags: Ghana Med J Source Type: research
Authors: Antwi S PMID: 31741489 [PubMed - in process]
Source: Ghana Medical Journal - Category: African Health Tags: Ghana Med J Source Type: research
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Source: Anesthesia and Analgesia - Category: Anesthesiology Authors: Tags: Anesth Analg Source Type: research
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Source: Kidney International - Category: Urology & Nephrology Tags: In This Issue Source Type: research
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Source: Kidney International - Category: Urology & Nephrology Authors: Tags: Nephrologists Sans Fronti ères Source Type: research
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Source: Kidney International - Category: Urology & Nephrology Authors: Tags: Commentary Source Type: research
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Source: Kidney International - Category: Urology & Nephrology Authors: Tags: Commentary Source Type: research
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Source: Kidney International - Category: Urology & Nephrology Authors: Tags: Make Your Diagnosis Source Type: research
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Source: Surgery (Oxford) - Category: Surgery Source Type: research
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