Pregnant mother diagnosed with terminal cancer refuses to have an early C-section

Indira Jayasuriya, 39, from Bromley, Kent, was first diagnosed with breast cancer in 2008 and later got the all clear - but discovered the disease returned while pregnant with her second child.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news

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Publication date: Available online 13 June 2019Source: Stem Cell ReportsAuthor(s): Lu Tian, Marie-José Truong, Chann Lagadec, Eric Adriaenssens, Emmanuel Bouchaert, Hélène Bauderlique-Le Roy, Martin Figeac, Xuefen Le Bourhis, Roland P. BouretteSummaryDuring normal mammary gland development, s-SHIP promoter expression marks a distinct type of mammary stem cells, at two different stages, puberty and early mid-pregnancy. To determine whether s-SHIP is a marker of mammary cancer stem cells (CSCs), we generated bitransgenic mice by crossing the C3(1)-SV40 T-antigen transgenic mouse model of breast cancer, a...
Source: Stem Cell Reports - Category: Stem Cells Source Type: research
Conclusion: Our study found that PID was associated with increased risks of gynecologic and urinary tract cancer but not colorectal or breast cancer. The information may lead to a strategy for cancer prevention and a reasonable healthcare usage through understanding PID epidemiology and controlling the inflammatory responses.
Source: Journal of Cancer - Category: Cancer & Oncology Authors: Tags: Research Paper Source Type: research
Abstract A 35-year-old 30-week pregnant woman was referred to our institution for initial staging of a triple negative invasive ductal carcinoma of the left breast. To avoid fetal radiation exposure from CT, a whole-body F-FDG PET/MRI was performed. Simultaneous acquisition of PET, T1-, T2-, and diffusion-weighted sequences revealed left axillary node extension and no distant metastases. Fetal radiation dose was estimated at 1.9 mGy. Interestingly, low fetal brain uptake and high symmetrical myocardial metabolism in both ventricles were found. Delivery was induced at 37 weeks of amenorrhea, and the patient underwe...
Source: Clinical Genitourinary Cancer - Category: Cancer & Oncology Authors: Tags: Clin Nucl Med Source Type: research
Purpose: With the trend towards delayed child-bearing, the incidence of pregnancy-associated breast cancer (PABCs) is rising and remains an important clinical problem. The aim of this national retrospective study was to describe the current practice of PABCs and any variation in the provision of care and adherence to treatment.
Source: Clinical Oncology - Category: Radiology Authors: Source Type: research
In conclusion, ASB6 could be a potential predictor and therapeutic target in patient with PABC. PMID: 31171715 [PubMed - as supplied by publisher]
Source: Bioscience Reports - Category: Biomedical Science Authors: Tags: Biosci Rep Source Type: research
A large international study looked at whether pregnancy is safe after breast cancer for women who have a BRCA mutation.
Source: CancerNetwork - Category: Cancer & Oncology Authors: Source Type: news
Abstract Emtricitabine (FTC) is a first-line antiviral drug recommended for treatment of acquired immune deficiency syndrome during pregnancy. We hypothesized that transporters located in the placenta contribute to FTC transfer across the blood-placenta barrier. BeWo cells, cell models with stable expression of transporter genes, primary human trophoblast cells (PHTCs) and small interfering (si)RNAs were applied to demonstrate which transporters were involved. FTC accumulation in BeWo cells was reduced markedly by inhibitors of equilibrative nucleoside transporters (ENTs), concentrative nucleoside transporters (CN...
Source: Antimicrobial Agents and Chemotherapy - Category: Microbiology Authors: Tags: Antimicrob Agents Chemother Source Type: research
Conclusions:The programme ensured good compliance with screening, referral and treatment indicating feasibility and acceptability of CBE based BC screening programme by the community.Keywords:Awareness, breast cancer, compliance, counseling, screening
Source: International Journal of Preventive Medicine - Category: International Medicine & Public Health Source Type: research
PGC-1α induced browning promotes involution and inhibits lactation in mammary glands. Cell Mol Life Sci. 2019 Jun 01;: Authors: Piccinin E, Morgano A, Peres C, Contursi A, Bertrand-Michel J, Arconzo M, Guillou H, Villani G, Moschetta A Abstract The PPARγ coactivator 1α (PGC-1α) is a transcriptional regulator of mitochondrial biogenesis and oxidative metabolism. Recent studies have highlighted a fundamental role of PGC-1α in promoting breast cancer progression and metastasis, but the physiological role of this coactivator in the development of mammary glands is still unkno...
Source: Cellular and Molecular Life Sciences : CMLS - Category: Cytology Authors: Tags: Cell Mol Life Sci Source Type: research
Abstract The anti-inflammatory diet is based on two diets that have been shown to have many positive health effects-the Mediterranean diet and the Okinawan diet. The anti-inflammatory diet is more than just a prescription for healthy food, but rather a way of life characterized by a plant-based diet and a pattern of living that includes eating a diverse range of locally grown foods eaten in season, conviviality, culinary activities, physical activity, and rest. The Mediterranean diet has been shown to reduce the burden and even prevent the development of cardiovascular disease, breast cancer, depression, colorecta...
Source: Pediatric Annals - Category: Pediatrics Authors: Tags: Pediatr Ann Source Type: research
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