A Systematic Review of the Risks Factors Associated with the Onset and Natural Progression of Hydrocephalus.

A Systematic Review of the Risks Factors Associated with the Onset and Natural Progression of Hydrocephalus. Neurotoxicology. 2016 Mar 18; Authors: Walsh S, Donnan J, Morrissey A, Sikora L, Bowen S, Collins K, MacDonald D Abstract The purpose of this study was to systematically assess and synthesize the world literature on risk factors for the onset and natural progression of hydrocephalus, thereby providing a basis for policy makers to identify appropriate risk management measures to mitigate the burden of disease in Canada. Evidence for risk factors was limited for both onset and progression. Two meta-analyses that examined a risk factor for onset met the inclusion criteria. One found a significant protective effect of prenatal vitamins among case control studies, but not cohort/randomized controlled trials (RCTs). The second found maternal obesity to be a significant risk factor for congenital hydrocephalus. Significant risk factors among 25 observational studies included: biological (multiple births, maternal parity, common cold with fever, maternal thyroid disease, family history, preterm birth, hypertension, ischemic heart disease, ischemic ECG changes, higher cerebrospinal fluid protein concentration following vestibular schwannoma); lifestyle (maternal obesity, high-density lipoprotein (HDL) cholesterol, maternal diabetes, maternal age), healthcare-related (caesarean section, interhospital transfer, drainage duration followin...
Source: Neurotoxicology - Category: Neurology Authors: Tags: Neurotoxicology Source Type: research