CB2 cannabinoid receptor is involved in the anti-inflammatory effects of leptin in a model of traumatic brain injury.

CONCLUSIONS AND IMPLICATIONS: Since some of the beneficial effects of leptin were not evident in the presence of AM630, our results suggest that CB2 receptor might be involved in the full expression of the neuroprotective effects of the hormone. These findings open new avenues for the study of leptin as a therapeutic treatment for TBI and enhance the importance of CB2 receptor in TBI pathophysiology and recovery. PMID: 27006282 [PubMed - as supplied by publisher]

http://www.ncbi.nlm.nih.gov/pubmed/27006282?dopt=Abstract

Source: Experimental Neurology - March 18, 2016 Category: Neurology Authors: Lopez-Rodriguez AB, Mela V, Acaz-Fonseca E, Garcia-Segura LM, Viveros MP Tags: Exp Neurol Source Type: research