Effects of 1,25-dihydroxyvitamin D3 on Macrophage Cytokine Secretion Stimulated by Porphyromonas gingivalis.

Effects of 1,25-dihydroxyvitamin D3 on Macrophage Cytokine Secretion Stimulated by Porphyromonas gingivalis. Jpn J Infect Dis. 2016 Mar 18; Authors: Xu QA, Li ZF, Zhang P, Cao LH, Fan MW Abstract Vitamin D has been known to be closely associated with periodontitis while the exact mechanisms remain to be clarified. The present study aimed to investigate the influence of 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) on porphyromonas gingivalis (Pg)-stimulated cytokine production by macrophages and the involved signaling pathways. The main observation was that 1,25(OH)2D3 inhibited Pg-induced IL-6 cytokine expression while improved the expression of anti-inflammatory cytokine IL-10. Further analyses showed that 1,25(OH)2D3 decreased the p38 MAPK and ERK1/2 phosphorylation. Inhibited phosphorylation of p38 MAPK and ERK1/2 was proved to be associated with decreased level of IL-6 expression, but not related to increased level of IL-10 expression in macrophages stimulated with Pg. These results suggest that 1,25(OH)2D3 may exert its anti-inflammatory effects on Pg-stimulated macrophages partly through its inhibitory effect on the p38 MAPK and ERK1/2 signaling pathway. PMID: 27000452 [PubMed - as supplied by publisher]
Source: Japanese Journal of Infectious Diseases - Category: Infectious Diseases Authors: Tags: Jpn J Infect Dis Source Type: research