Brachytherapy: Where Has It Gone...Again? CORRESPONDENCE
Brachytherapy plays an integral role in the management of gynecologic malignancies. The use of brachytherapy in combination with external beam radiation has been correlated with an improvement in both local control and survival in patients with advanced stage cancers of the cervix and endometrium (1 –4). The widespread adoption of image-guided adaptive brachytherapy over the past decade has allowed treatment techniques, including the use of various applicators and interstitial needles, to become increasingly more complex and individualized.
To utilize failure mode and effects analysis (FMEA) to effectively direct the transition from the Elekta microSelectron to the Flexitron high dose-rate afterloader system.
We report the safety and effectiveness of this technique.MethodsWe conducted a retrospective analysis of 16 consecutive patients who employed this technique from January 2015 to March 2018. The radioactive feeding tube was made by binding the125I seed chain on the feeding tube. Under fluoroscopic guidance, the tube was inserted into the obstructed esophagus, with the seed chain crossing over the segment of malignant esophageal obstruction. Technical success rate, dysphagia score, procedure time and complications were analyzed. Kaplan –Meier analysis was used to analyze the survival time.ResultsThe radioactive feeding...
We present a case report of a patient with uterine primitive neuroectodermal tumor (PNET). The patient underwent surgical management followed by pelvic radiation and intravaginal brachytherapy. Following a stable interval, the patient was found to have new onset spinal, pulmonary, and adrenal metastatic disease. She was subsequently started on high dose carboplatin and etoposide. An interval reduction of her metastatic disease was observed after three cycles. We conclude that a multimodal approach, including platinum-based adjuvant chemotherapy with etoposide, can be effective in patients who present with residual or recur...
To examine the variability in prescribed dose due to contouring variations in intracavitary image-guided adaptive brachytherapy for cervical cancer. To identify correlations between dosimetric outcomes and delineation uncertainty metrics.
Conditions: Brachytherapy; Squamous Cell Carcinomas Intervention: Radiation: 3D-printing Template-assisted CT-guided I-125 Seed Implantation Sponsor: Peking University Third Hospital Not yet recruiting
Computer-aided detection (CAD) software developer iCAD said that its Xoft Axxent...Read more on AuntMinnie.comRelated Reading: iCAD features AI software for breast imaging at RSNA iCAD features Xoft Axxent upgrades at ASTRO 2019 iCAD to highlight AI for tomosynthesis at ECR iCAD touts clinical results with Xoft Axxent brachytherapy iCAD touts study on radiation therapy savings
Comprehensive surgery with adjuvant therapy is standard of care for high-risk endometrial cancers, whereas upfront radiotherapy with brachytherapy is indicated for inoperable/unresectable patients, irrespective of risk. We evaluated outcomes for inoperable/unresectable patients with high-risk endometrial cancer (HREC: stage III and/or grade 3) and low-risk endometrial cancer (LREC: stage I/II and grade 1/2) treated with upfront radiotherapy.
A common treatment planning technique for eye plaque brachytherapy is to model the tumor as an ellipse. For posterior tumors near the optic disc and fovea, this approach may lead to overlap between tumor and the organ at risk (OAR). We hypothesized that a superior plan can be generated by modeling the actual tumor shape.
Condition: Prostate Cancer Interventions: Drug: 68-Ga RM2.; Drug: 68-Ga PSMA11; Device: PET/MRI Sponsor: Andrei Iagaru Recruiting