Decreased blood vessel leakage can improve cancer therapy and reduce tumor spread

(Uppsala University) Cancer therapy is often hampered by the accumulation of fluids in and around the tumor, which is caused by leakage from the blood vessels in the tumor. Researchers at Uppsala University now show how leakage from blood vessels is regulated. They have identified a novel mechanism whereby leakage can be suppressed to improve the result of chemotherapy and reduce the spread of tumors in mice. The results have been published in the scientific journal Nature Communications.
Source: EurekAlert! - Cancer - Category: Cancer & Oncology Source Type: news

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In conclusion, our results show that the effect of paclitaxel and oxaliplatin on the structural plasticity of DRG is retained ex vivo (for at least 30 days) and suggest the use of DRG explants derived from chemotherapy-treated mice as an efficient method to investigate the mechanisms underlying CIPN and test for possible therapeutic targets.
Source: Neuroscience Letters - Category: Neuroscience Source Type: research
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Source: International Journal of Cancer - Category: Cancer & Oncology Authors: Tags: Research Article Source Type: research
ConclusionThis review provided a comprehensive examination of available options for children who have OM. The results support the possibility of a positive effect of palifermin on reducing OM in children receiving cancer therapy.
Source: Pediatric Blood and Cancer - Category: Cancer & Oncology Authors: Tags: REVIEW Source Type: research
ConclusionsFindings from this study highlight that real-world experience of docetaxel may differ from that observed in clinical trials and that care must be taken to ensure that treatment options are tailored to the needs of individual patients to promote not only how long patients survive but also the quality of that survival.FundingJanssen
Source: Advances in Therapy - Category: Drugs & Pharmacology Source Type: research
ConclusionApplication of cytostatic drugs in combination with adaptogenic plant extracts induced significant changes in transcriptome-wide microarray profiles of neuroglial cells. These changes indicate on potential beneficial effects of adaptogens on FEC induced adverse events in cancer chemotherapy.Graphical abstract
Source: Phytomedicine - Category: Drugs & Pharmacology Source Type: research
Oral and pharyngeal cancer is the most common malignant human cancers. Chemotherapy is an effective approach for anti-oral cancer therapy, while the drug tolerance and resistance remain a problem for oral canc...
Source: BMC Complementary and Alternative Medicine - Category: Complementary Medicine Authors: Tags: Research article Source Type: research
Publication date: January 2019Source: Biomedicine &Pharmacotherapy, Volume 109Author(s): Xin Zhang, Kaikai Ding, Jian Wang, Xingang Li, Peng ZhaoAbstractGlioblastoma multiforme (GBM) is the most common and aggressive primary human brain tumor. Although comprehensive therapies combining radiotherapy and chemotherapy after surgery can prolong survival, the prognosis is still poor with a median survival of only 14.6 months. Chemoresistance is one of the major causes of relapse as well as poor survival in glioma patients. Therefore, novel strategies to overcome chemoresistance are desperately needed for improved treatment ...
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research
Publication date: Available online 30 October 2018Source: Colloids and Surfaces A: Physicochemical and Engineering AspectsAuthor(s): Hongchao Ma, Shuo Li, Hao Zhang, Yanhui Wei, Lei JiangAbstractThe combined therapeutic strategy have aroused significant interest in cancer therapy due to its enhanced treatment efficacy and reduced side effects. This paper describes the combined chemo- and photothermal therapy of cancer based on PDA@(PDDA-ADA)3-Dox nanocomposites. Polydopamine (PDA) serves not only as photothermal agent with strong near infrared absorbance and high energy conversion efficiency, but also as a core material to...
Source: Colloids and Surfaces A: Physicochemical and Engineering Aspects - Category: Chemistry Source Type: research
(Natural News) Two thousand years ago, Hippocrates said that food should be the medicine. Recent developments mirror that ancient saying when it comes to cancer therapy. An Indian study indicated that nutritional therapy possessed certain advantages over chemotherapy as a means of treating the disease. Cancer comes in many forms that attack various parts of...
Source: NaturalNews.com - Category: Consumer Health News Source Type: news
AbstractMore than 3000 clinical trials are evaluating the clinical activity of the PD-1 checkpoint inhibitors as monotherapies and in combinations with other cancer therapies [1]. The PD-1 checkpoint inhibitors are remarkable for their clinical activities in shrinking tumors across a wide range of tumor types, in causing durable responses, and in their tolerability. These attributes position them as favorable agents in clinical combinations. Historically, approaches to cancer therapy combinations focused on agents with orthogonal activities to avoid shared resistance mechanisms and shared toxicities. Although CTLA-4/PD-1 c...
Source: Seminars in Immunopathology - Category: Pathology Source Type: research
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