Simultaneous cryptococcal and tuberculous meningitis in a patient with systemic lupus erythematosus

We describe a patient with systemic lupus erythematosus diagnosed with simultaneous cryptococcal and TB meningitis who had a poor response to intravenous liposomal amphotericin B and fluconazole, but was successfully treated with intraventricular amphotericin B, in addition to anti-TB therapy.
Source: Journal of Microbiology, Immunology and Infection - Category: Microbiology Source Type: research

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This study reports the validation of an enzyme-linked immunosorbent assay (ELISA) to detect bovine tuberculosis as an ancillary test to TST in dairy farms in Argentina.The estimated validation parameters were within the established requirements of the World Organization for Animal Health (OIE). The test demonstrated high repeatability, with coefficients of variation
Source: The Veterinary Journal - Category: Veterinary Research Source Type: research
This article focus on the synthesis of three 5-coordinated Sn(IV) complexes based on carboxylate ligand: 4-((4-methoxy-2-nitrophenyl)amino)-4-oxobutanoic acid. The complexes were characterized both in solid state (FT-IR, single crystal XRD and micro elemental analysis) as well as in solution state (1H, 13C and 119Sn NMR) and their results demonstrate that the carboxylate moiety of the ligand is linked with Sn atom. A 5-coordinated trigonal bipyramidal structure was obtained from crystallographic data for the reported complexes with little bit distortion from the ideal structure. Preliminary antifungal screening showed that...
Source: Journal of Molecular Structure - Category: Molecular Biology Source Type: research
The multifaceted Notch signaling pathway appears to tame the autoimmune response and protect lupus-prone mice from inflammation and damage.
Source: Kidney International - Category: Urology & Nephrology Authors: Tags: Commentary Source Type: research
ConclusionMore effective thromboprophylaxis and pre-test assessment is necessary for EOC patients. For prediction VTE events, D-dimer levels (>4.215 μg/ml) were the independent predictors before operation. Age and debulking surgery were the independent predictors post operation.
Source: European Journal of Surgical Oncology (EJSO) - Category: Surgery Source Type: research
Publication date: Available online 14 December 2019Source: Best Practice &Research Clinical RheumatologyAuthor(s): Ben Mulhearn, Sarah L. Tansley, Neil J. McHughAbstractAutoimmune connective tissue diseases are heterogeneous rheumatic diseases with the potential to affect multiple body systems. Autoantibodies are a characteristic feature of these diseases and are typically highly disease specific. In addition to aiding diagnosis, many autoantibodies have established associations with clinically important disease complications including internal organ involvement. In this chapter, we review the autoantibodies relevant t...
Source: Best Practice and Research Clinical Rheumatology - Category: Rheumatology Source Type: research
Conclusion: For uveitis of unknown cause, diagnostic PPV is an effective, reliable, and relatively safe procedure for establishing the definite diagnosis and guiding further treatment. Positive therapeutic effect could also be achieved.
Source: RETINA - Category: Opthalmology Tags: Original Study Source Type: research
Source: BMJ News - Category: General Medicine Source Type: research
Only three new treatments available in 10 or more poorer countries, report findsMany antibiotics are unavailable in poorer countries despite higher infection rates, exacerbating the threat of drug-resistant superbugs, according to a report to bepresented to world leaders and the bosses of top pharmaceutical companies in Davos.The report, released by the Access to Medicine Foundation, an Amsterdam-based non-profit group, also shows that the number of new treatments being developed for common infectious diseases such as pneumonia, tuberculosis and gonorrhoea has fallen.Continue reading...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: Antibiotics Business Davos 2020 Drugs MRSA and superbugs Health Source Type: news
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Source: Expert Opinion on Drug Discovery - Category: Drugs & Pharmacology Authors: Source Type: research
Understanding the functions of disease-associated noncoding variants is essential for understanding the molecular mechanisms driving diseases with a genetic cause and for identifying therapeutic targets. Combined computational and experimental analyses have demonstrated that IRF5 is hyperactivated by a pathogenic allele of TNPO3 through long-distance chromatin looping. This finding identifies a molecular mechanism contributing to the polygenic autoimmune diseases of systemic lupus erythematosus and systemic sclerosis.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Commentary Source Type: research
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