Early recurrence of proliferative glomerulonephritis with monoclonal immunoglobulin deposits in a renal allograft.

Early recurrence of proliferative glomerulonephritis with monoclonal immunoglobulin deposits in a renal allograft.
Saudi J Kidney Dis Transpl. 2016 Mar-Apr;27(2):381-385
Authors: Tewari R, Joshi K, Kumar A, Rayat CS, Iyer R, Sakhuja V, Minz M
Abstract
Proliferative glomerulonephritis with monoclonal immunoglobulin deposits (PGNMIDs) is a clinico-pathologic entity, the recurrence of which in the renal allograft has only recently been described. A 55-year-old male presented with rapid deterioration of renal function. Light microscopy showed membranoproliferative glomerulonephritis with kappa light chain restriction and only one sub-class of IgG. He subsequently underwent renal transplant. Two months later, he developed acute graft dysfunction. Renal biopsy showed a recurrence of the disease. Work up for multiple myeloma was positive. Membranoproliferative pattern of injury in the posttransplant setting has a wide range of differential diagnosis, PGNMID being one of them.
PMID: 26997395 [PubMed - as supplied by publisher]

Source: Saudi Journal of Kidney Diseases and Transplantation - February 29, 2016 Category: Urology & Nephrology Authors: Tewari R, Joshi K, Kumar A, Rayat CS, Iyer R, Sakhuja V, Minz M Tags: Saudi J Kidney Dis Transpl Source Type: research