Drug combination reduces polyps for patients with high risk for colorectal cancer

In a recent study, researchers randomly assigned 92 patients with familial adenomatous polyposis to the drugs sulindac twice daily and erlotinib daily (n = 46) or placebo (n = 46) for 6 months. The outcome of the study showed very positive results for those with a high risk of colorectal cancer
Source: ScienceDaily Headlines - Category: Science Source Type: news

Related Links:

ABSTRACT BACKGROUND: Polypectomy of colorectal polyps is the mainstay of colorectal cancer prevention. Identification of the best polypectomy technique is imperative. OBJECTIVE: This review aims at comparing efficacy of nine different resection methods for small colorectal polyps (
Source: Arquivos de Gastroenterologia - Category: Gastroenterology Source Type: research
This study investigate the potential preventive effect of Lactobacillus acidophilus and Lactobacillus plantarum in patients with polyps or colorectal cancer (CRC). METHODS: A total of 77 samples were selected in the form of three groups including individuals suffering from CRC, polyps and healthy subjects. Genomic DNA of fecal specimens and standard strains were extracted and amplified employing primers targeting of the 16S rRNA gene for initial detection. Absolute Real Time PCR quantification was used to determine the copy of the bacterial expression per gram of feces. RESULTS: No significant difference were observed betw...
Source: Arquivos de Gastroenterologia - Category: Gastroenterology Source Type: research
This study was aimed at characterizing isolates collected from polyps and adjacent tissue in comparison with those from normal mucosa.From colonoscopy biopsies, 1500 E. coli isolates were retrieved and genotyped; 272 were characterized for phylogroup and major phenotypic traits (i.e., biofilm formation, motility, hemolysins, and proteases). Selected isolates were analyzed for extraintestinal pathogenic E. coli (ExPEC)-associated virulence genes and in vivo pathogenicity using Galleria mellonella.The majority of isolates collected from polyps were strong biofilm and poor protease producers, whereas those isolates from norma...
Source: Microbes and Infection - Category: Infectious Diseases Source Type: research
Check-Cap (NSDQ:CHEK) said its X-ray-enabled, colorectal cancer-screening capsule will have a pilot study in the United States. The Isfiya, Israel-based startup makes the C-Scan System, an ingestible capsule used to detect precancerous polyps without the need for laxatives or an invasive procedure. The C-Scan system uses an ultra-low dose X-ray capsule, an integrated positioning, control, and recording system, and proprietary software to generate a 3D map of the inner lining of the colon. It received approval from Israel’s Ministry of Health Medical Device division (AMAR) and the CE Mark...
Source: Mass Device - Category: Medical Devices Authors: Tags: Blog Clinical Trials Implants News Well Oncology Research & Development Check-Cap FDA New York University Source Type: news
Low-dose aspirin can lower your risk for colon cancer but fewer than half the people who already have polyps aren’t taking it.
Source: WebMD Health - Category: Consumer Health News Source Type: news
TUESDAY, Feb. 12, 2019 -- Aspirin is underused to reduce the risk for colorectal cancer among patients with advanced colorectal polyps, according to a study recently published in The American Journal of Medicine. Noting that the U.S. Preventive...
Source: Drugs.com - Pharma News - Category: Pharmaceuticals Source Type: news
Conclusions: These results suggest that SSAs develop at a young age, but have a prolonged dwell time and are unlikely to develop into cancer in patients younger than 60 years of age. These findings highlight the need for further targeted research to determine the most appropriate surveillance intervals for young patients with sporadic SSAs.
Source: Journal of Clinical Gastroenterology - Category: Gastroenterology Tags: ONLINE ARTICLES: Original Articles Source Type: research
Goals: The aim of this study was to compare a new, full-spectrum endoscope (Fuse; EndoChoice, Alpharetta, GA) to standard forward-viewing colonoscopy in the detection of colorectal neoplasms. Background: Colonoscopy, the gold standard for the detection of colorectal cancer, fails to detect 22% to 28% of polyps, increasing the risk of interval cancer. Endoscopic improvement of the adenoma detection rate decrease interval carcinomas. Full-spectrum endoscopy (FUSE) (330-degree field of view), in a tandem study, has been shown to reduce the adenoma miss rate. Study: Prospective, randomized study of 249 patients in pati...
Source: Journal of Clinical Gastroenterology - Category: Gastroenterology Tags: ALIMENTARY TRACT: Original Articles Source Type: research
Incomplete resection of polyps could be an important cause of post-colonoscopy colorectal cancer. However, it is difficult to study progression of incompletely removed polyps or their clinical importance. We aimed to estimate incomplete polyp resection using risk of metachronous neoplasia per colon segment.
Source: Clinical Gastroenterology and Hepatology - Category: Gastroenterology Authors: Source Type: research
MONDAY, Feb. 11, 2019 -- People with colon polyps spotted during screening are at higher risk for colon cancer. But while low-dose aspirin could lower the odds for the disease, too few patients adopt the regimen, new research shows. Advanced colon...
Source: Drugs.com - Daily MedNews - Category: General Medicine Source Type: news
More News: Cancer | Cancer & Oncology | Colorectal Cancer | Gastrointestinal Polyps | Polyps | Science | Study | Tarceva