Sulindac plus erlotinib reduces duodenal polyp burden
Combination therapy with sulindac and erlotinib reduced the burden of duodenal polyps in a preliminary study involving 92 patients with familial adenomatous polyposis (FAP), which was reported online...
Authors: McCarthy AJ, O'Reilly SM, Shanley J, Geraghty R, Ryan EJ, Cullen G, Sheahan K Abstract Background: As the malignant potential of sessile serrated lesions/polyps (SSL/Ps) and traditional serrated adenomas (TSAs) has been clearly demonstrated, it is important that serrated polyps are identified and correctly classified histologically. Aim: Our aim was to characterize the clinicopathological features of a series of SSL/Ps &TSAs, to assess the accuracy of the pathological diagnosis, the incidence, and the rate of dysplasia in SSL/Ps &TSAs. Methods: We identified all colorectal serrated polyps b...
This article will address the development of FAP, its presentation, and potential treatment strategies that may be used by nurse practitioners. PMID: 30880794 [PubMed - in process]
AbstractObjectiveChronic rhinosinusitis with nasal polyps (CRSwNP) is a chronic inflammatory disease. The surrogate indicating biomarkers in patients with CRSwNP need further evaluation. The aim of this study was to investigate the association of thymic stromal lymphopoietin (TSLP) and amphiregulin (AREG) cytokines in patients with CRSwNP.MethodsSinonasal tissue samples were collected from 33 patients with CRSwNP and 29 controls. Levels of AREG, IL-19, IL-21, IL-25, IL-33 and TSLP in nasal polyp and control sinonasal tissues were determined following the enzyme-linked immunosorbent assay method.ResultsWe found that AREG, I...
Conditions: Chronic Rhinosinusitis (Diagnosis); Surgery Interventions: Procedure: radical endoscopic sinus surgery (RESS) plus Draf 3 surgery.; Procedure: radical endoscopic sinus surgery (RESS); Procedure: functional endoscopic sinus surgery (FESS) Sponsor: Beijing Tongren Hospital Completed
The aim of our study was to investigate the prevalence and natural long-term progression of gallbladder polyps in a random sample of the general population.
ConclusionDespite increasing self-reported utilization of optical colonoscopy from 2010 to 2015, survey results suggest that CT colonography awareness (∼16%) and utilization (∼1%) remain low. Improved public awareness and coverage expansion to Medicare-aged populations will promote improved CT colonography utilization and overall colorectal cancer screening rates.
The accuracy of optical technologies in differentiating cancerous from benign tissue is"insufficient" for most routine clinical applications, including diagnosing pre-cancerous colorectal polyps, researchers say.Reuters Health Information
AbstractBackground and AimWe identified patients without medical record evidence of up-to-date colorectal cancer (CRC) screening and sent an invitation letter to self-schedule a colonoscopy without requiring prior primary care or gastroenterologist consultation. The aim of the study was to evaluate the response rate to the letter and factors associated with colonoscopy completion.MethodsA computer algorithm invited patients not up to date with CRC screening, with an INR
Colon cancer screening reduces deaths from colorectal cancer. Screening rates have plateaued; however, studies have found that giving patients a choice between different screening tests improves adherence. CT colonography is a minimally invasive screening test with high sensitivity for colonic polyps (>1 cm). With increasing insurance coverage of CT colonography nationwide, there are limited estimates of CT colonography utilization over time. Our purpose was to estimate CT colonography utilization over time using nationally representative cross-sectional survey data.
We examined whether prophylactic closure of the mucosal defect with hemoclips after polyp resection reduces the risk of bleeding.