miR-92b promotes tumor proliferation, migration, and invasion by targeting RECK in osteosarcoma

In this study, we focused on the expression, function, and mechanisms of miR-92b in osteosarcoma development. miR-92b was upregulated in osteosarcoma cell lines and tissues.miR-92b upregulation was correlated with poor prognosis in osteosarcoma. Overexpression ofmiR-92b promoted osteosarcoma cell proliferation,migration, and invasion, which was abrogated by miR-92b inhibition.Reversion-inducing-cysteine-rich protein with kazal motifs (RECK) was identified as the direct and functional target of miR-92b in osteosarcoma. Importantly, restoring RECK expression abrogated increases in cell growth, motility, and invasiveness induced by miR-92b. RECK was down-regulated in osteosarcoma tissues, and its expression level negatively correlated with miR-92b. Collectively, our results indicate miR-92b acts as an oncogenic miRNA and may be a therapeutic target in osteosarcoma.

Source: Clinical Science - March 18, 2016 Category: Biomedical Science Authors: Zhou, Z., Wang, Z., Wei, H., Wu, S., Wang, X., Xiao, J. Tags: PublishAheadOfPrint Source Type: research