I Am My Mother's Chimera. Chances Are, So Are You.

For years the concept of a "genetic chimera" -- an individual with two genetically distinct cells lines in his/her body -- has sparked the imagination of writers: from Stephen King to Michael Crichton, from CSI to The Office. The idea that an individual could harbor his/her own twin is creepy and intriguing at the same time. Recent advances in DNA sequencing technology have allowed us to probe much deeper into a person's genome, to the point that today scientists believe that chimerism could be far more common than what we originally thought. Chances are, you could be your own twin. But how surprised would you be if I told you that you are actually far more likely to be your mother's chimera than your unborn sibling's? Before the 1960s, it was believed that the placenta was a perfect barrier between mother and fetus, and no blood or cells could trespass it in either direction. Today we know that there's actually a two-way exchange of cells between mother and fetus during pregnancy. What's even more surprising is that these "extraneous" cells outlast the duration of the pregnancy and can in fact be found in the child and/or the mother years after birth. Male DNA has been found in women years after they had given birth to their sons. In fact, fetal cells are released in high quantities during spontaneous abortions, hence can be found even in women who have never delivered, so long as at some point in their lives they became pregnant. Conversely, maternal...
Source: Science - The Huffington Post - Category: Science Source Type: news

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Authors: Campello E, Spiezia L, Adamo A, Simioni P Abstract INTRODUCTION: Fifty-three years after the first description of an inherited prothrombotic condition (antithrombin deficiency), our knowledge on hereditary and acquired causes of hypercoagulability that can predispose carriers to venous thromboembolism (VTE) has greatly improved. Areas covered: Main causes of hereditary thrombophilia are summarized alongside new prothrombotic mutations recently discovered. The main causes of acquired thrombophilia, and namely, antiphospholipid antibody syndrome and hyperhomocysteinemia, are also discussed together with othe...
Source: Expert Review of Hematology - Category: Hematology Tags: Expert Rev Hematol Source Type: research
Kaitlyn Dorman, 17, from Baltimore, Maryland, was diagnosed with pilocytic astrocytoma, a childhood brain tumor, when she was nine years old. An experimental drug has 'cured' her, doctors say.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
Abstract Laser ablation inductively coupled plasma - mass spectrometry (LA-ICP-MS) is proposed for a better understanding of metals and proteins distribution in micrometre structures of human brain tissues. Simultaneous absolute quantitative imaging of Fe and ferroportin (FPN), in 5 µm thick tissue sections of the stratum pyramidale of hippocampus CA1 region, was carried out for Alzheimer disease (AD) patients and healthy controls (HC). For the imaging of FPN by LA-ICP-MS, antibodies were labelled via carbodiimide crosslinking with fluorescent gold nanoclusters (AuNCs) of 2.2 nm diameter, enabling a high...
Source: Talanta - Category: Chemistry Authors: Tags: Talanta Source Type: research
obo-Castañón MJ Abstract Cancer diagnosis based on serum biomarkers requires receptors of extreme sensitivity and selectivity. Tunability of aptamer selection makes them ideal for that challenge. However, aptamer characterization is a time-consuming task, not always thoroughly addressed, leading to suboptimal aptamer performance. In this work, we report on the affinity characterization and potential usage of two aptamers against a candidate cancer biomarker, the neutrophil gelatinase-associated lipocalin (NGAL). Electrochemical sandwich assays on Au electrodes and SPR experiments showed a restricted ...
Source: Talanta - Category: Chemistry Authors: Tags: Talanta Source Type: research
Abstract Adenosine is closely related to the development of cancer, and it can be regarded as a biomarker for cancer diagnosis and therapy. Here, a T7 exonuclease (T7 Exo)-assisted and target-triggered cascade dual recycling signal amplification strategy was developed for the sensitive and specific detection of adenosine. In this strategy, a capture strand (Cap)-inhibit strand (Inh) duplex and a DNA hairpin with intact G-quadruplex sequence are designed. In the presence of adenosine, Cap binds with adenosine specifically to form Cap-adenosine complex with recessed 5'-hydroxyl termini, causing the release of Inh. U...
Source: Talanta - Category: Chemistry Authors: Tags: Talanta Source Type: research
Abstract To fight against diabetes mellitus, from which more than 400 million people suffer in the world, the patients have to puncture their fingers 4-5 times a day for the blood glucose level checks when using a glucometer, causing invasive pain and the risk of infection. Therefore, non-invasive method has been urged for blood glucose monitoring, among which the mid-infrared spectroscopy (Mid-IR) response of interstitial fluid was found to be promising. However, despite the prolonged effort, the accuracy still falls below the FDA's requirement. To break this barrier which lasted for almost three decades, we disc...
Source: Talanta - Category: Chemistry Authors: Tags: Talanta Source Type: research
Abstract Anterior gradient protein 2 homolog (AGR) is a potential tumor biomarker and plays an important role in tissue development and regeneration. The intracellular detection of AGR is rarely reported. By conjugating the AGR aptamer with a cytosine base sequence as Ag cluster template, a highly fluorescent probe (MA@AgNCs) was synthesized for targeting intracellular AGR. The MA@AgNCs display a maximum fluorescence peak at 565 nm, and possess an excellent quantum yield (QY = 87.43%), small size, great biocompatibility, low toxicity, and good stability. Moreover, the as synthesized MA@AgNCs show high specific...
Source: Talanta - Category: Chemistry Authors: Tags: Talanta Source Type: research
In this study, a novel approach for preparing fluorescent boronic-acid-modified carbon dots (C-dots) for the detection of SA was developed. The functionalized C-dots were synthesized by a facile, one-step hydrothermal method using 3-pyridineboronic acid as the sole carbon source. The added SA selectively recognized the C-dots, leading to the fluorescence quenching of the C-dots in a linear range of 80-4000 μM with a detection limit of 54 μM. The as-developed boronic-acid nanoprobe was successfully applied for the detection of SA in human serum samples with satisfactory results. In addition, this method afforded r...
Source: Talanta - Category: Chemistry Authors: Tags: Talanta Source Type: research
Abstract Peroxynitrite (ONOO-) is an important reactive oxygen species (ROS), which can react with a variety of biologically active species and cause many diseases, such as cancer, neurodegenerative disorders. Herein, we develop a novel far-red fluorescent probe DCM-KA, which is equipping with α-ketoamide moiety caged DCM-NH2. The probe exhibits fluorescence off-on response to ONOO- over other biological interfering analytes by ONOO--induced α-ketoamide deprotection reaction. More importantly, the probe is biocompatible and has been successfully utilized to visualize endogenous ONOO- production in macr...
Source: Talanta - Category: Chemistry Authors: Tags: Talanta Source Type: research
(Reuters Health) - People with diabetes who regularly eat nuts may be less likely to develop heart disease than their counterparts who rarely, if ever, consume nuts, a U.S. study suggests.
Source: Reuters: Health - Category: Consumer Health News Tags: healthNews Source Type: news
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