I Am My Mother's Chimera. Chances Are, So Are You.

For years the concept of a "genetic chimera" -- an individual with two genetically distinct cells lines in his/her body -- has sparked the imagination of writers: from Stephen King to Michael Crichton, from CSI to The Office. The idea that an individual could harbor his/her own twin is creepy and intriguing at the same time. Recent advances in DNA sequencing technology have allowed us to probe much deeper into a person's genome, to the point that today scientists believe that chimerism could be far more common than what we originally thought. Chances are, you could be your own twin. But how surprised would you be if I told you that you are actually far more likely to be your mother's chimera than your unborn sibling's? Before the 1960s, it was believed that the placenta was a perfect barrier between mother and fetus, and no blood or cells could trespass it in either direction. Today we know that there's actually a two-way exchange of cells between mother and fetus during pregnancy. What's even more surprising is that these "extraneous" cells outlast the duration of the pregnancy and can in fact be found in the child and/or the mother years after birth. Male DNA has been found in women years after they had given birth to their sons. In fact, fetal cells are released in high quantities during spontaneous abortions, hence can be found even in women who have never delivered, so long as at some point in their lives they became pregnant. Conversely, maternal...
Source: Science - The Huffington Post - Category: Science Source Type: news

Related Links:

AbstractJuvenile systemic lupus erythematosus (jSLE) is a multisystem autoimmune disease of unpredicted course and prognosis. Rates of organ involvement in SLE are higher in children, and overt lupus nephropathy is more often a presenting manifestation of SLE in children than adults. Inflammatory soluble chemokine CXC motif-ligand 16 (sCXCL16) is an important pathogenic mediator in inflammatory diseases as SLE. Herein, we aimed to evaluate serum level of sCXCL16 in jSLE patients in comparison to healthy controls and to correlate it with disease activity and extent of cutaneous and renal affection, to detect its possible ro...
Source: Clinical Rheumatology - Category: Rheumatology Source Type: research
AbstractThe study aims to analyze the effects of induction treatment with cyclophosphamide (CYC) pulse therapy followed by maintenance treatment with other mild immunosuppressive agents on lung function in scleroderma (SSc) patients. Thirty patients with SSc (mean age 52  years, mean disease duration
Source: Clinical Rheumatology - Category: Rheumatology Source Type: research
AbstractTo investigate the value of lone anti-Smith antibody (anti-Sm) using Euroimmun line immunoassay (LIA) in a Chinese population. One thousand two hundred eight of 39,766 patients who were analyzed for anti-Sm had positive anti-Sm, and were divided into true group (having both positive Sm and nRNP/Sm bands) and lone group (only having Sm band without nRNP/Sm band). The proportions of clinical diagnosis of autoimmune diseases (AIDs), non-autoimmune diseases (NAIDs), concentration of C3, C4, and rheumatoid factor (RF), positive rate of autoantibodies of antinuclear antibody (ANA) profile, and titer of anti-Sm and ANA in...
Source: Clinical Rheumatology - Category: Rheumatology Source Type: research
Rebecca Lane, now 39, from Sherborne, Dorset, weighed 18st 5lbs (116.5kg) when she was diagnosed in July 2016. She was forced to have her uterus and cervix removed.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
Publication date: Available online 22 October 2018Source: Respiratory InvestigationAuthor(s): Naofumi ShinagawaAbstractBronchoscopy is one of the main techniques used for sampling lung tumor biopsies. In recent years, a large number of tumor specimens have been required to determine the best chemotherapy regimen for each patient; this personalized approach is known as precision medicine. In this review, radial endobronchial ultrasound; bronchoscopic navigation systems, including virtual bronchoscopic navigation and electromagnetic navigation; ultrathin bronchoscope,; and endobronchial ultrasound-guided transbronchial needl...
Source: Respiratory Investigation - Category: Respiratory Medicine Source Type: research
ConclusionProportion of SITC type 1 (persistent) in breast cancers on pre-treatment MRI as semi-automatically quantified using a CAD system is associated with absence of pathological complete response to neo-adjuvant chemotherapy with good specificity.
Source: Diagnostic and Interventional Imaging - Category: Radiology Source Type: research
CONCLUSIONS: This cohort will reveal determinants of cardiometabolic risk factors and cancer risk factors during childhood. PMID: 30344192 [PubMed - as supplied by publisher]
Source: Journal of Epidemiology - Category: Epidemiology Tags: J Epidemiol Source Type: research
In this study involving 3,650 postmenopausal women, the difference in life expectancy was compared in women experiencing early, normal, and late menopause, as well as in those with and without diabetes. Compared with late menopause (defined as menopause that occurs at age 55 years and older), the difference in life expectancy for women who experienced early menopause (defined as menopause that occurs at age 44 years or younger) was -3.5 years overall and -4.6 years in women without diabetes. Compared with age at normal menopause (defined as menopause that occurs at 45-54 years of age), the difference in life expectancy for...
Source: Fight Aging! - Category: Research Authors: Tags: Daily News Source Type: blogs
Stereotactic ablative radiotherapy (SABR) can greatly increase how long oligometastatic...Read more on AuntMinnie.comRelated Reading: ASTRO: Weekly breast radiation therapy is safe ASTRO: AI's rad therapy future is in predicting outcomes Study gives all-clear for skin cream during radiation therapy PET/CT predicts success of rad therapy for spinal mets Is radiation therapy warranted for DCIS postlumpectomy?
Source: AuntMinnie.com Headlines - Category: Radiology Source Type: news
This study shows that some genetic changes linked to cancer are present in surprisingly large numbers of normal cells. We still have a long way to go to fully understand the implications of these new findings, but as cancer researchers, we can't underestimate the importance of studying healthy tissue." Link: https://www.sanger.ac.uk/news/view/mutant-cells-colonise-our-tissues-over-our-lifetime
Source: Fight Aging! - Category: Research Authors: Tags: Daily News Source Type: blogs
More News: Alzheimer's | Atresia | Autoimmune Disease | Bile | Biology | Brain | Brain Cancers | Breast Cancer | Cancer | Cancer & Oncology | Cardiology | Children | Colon Cancer | Colorectal Cancer | Diabetes | Endocrinology | Gastroschisis Repair | Genetics | Health | Heart | Heart Transplant | Hormones | Kidney Transplant | Kidney Transplantation | Liver | Liver Transplant | Lung Transplant | Miscarriage | Neurology | Neuroscience | Pancreas | Pancreatic Cancer | Pathology | Pregnancy | Pregnancy and Breast Cancer | Science | Scleroderma | Skin | Study | Thyroid | Thyroid Cancer | Thyroiditis | Transplant Surgery | Transplants | University of Washington | Urology & Nephrology | Websites | Women