The C-terminal tail of polycystin-1 regulates complement factor B expression by Signal Transducer and Activator of Transcription 1.

In conclusion, our study reveals possible mechanisms of CFB up-regulation in ADPKD and a novel role of PC1-CTT on ADPKD associated inflammation. Furthermore our study suggests that targeting STAT1 may be a new strategy to prevent inflammation in the kidney of patients with ADPKD.
PMID: 26984954 [PubMed - as supplied by publisher]

Source: Am J Physiol Renal P... - March 16, 2016 Category: Urology & Nephrology Authors: Wu M, Chen M, Jing Y, Gu J, Mei S, Yao Q, Zhou J, Yang M, Sun L, Wang W, Hu H, Wüthrich RP, Mei C Tags: Am J Physiol Renal Physiol Source Type: research