Calmodulin kinase II inhibition limits the pro-arrhythmic Ca2+ waves induced by cAMP-phosphodiesterase inhibitors

Conclusion
Our results show that PDE inhibitors exert inotropic effects via PKA but lead to SCWs via both PKA and CaMKII activation partly via Epac2, suggesting the potential use of CaMKII inhibitors as adjuncts to PDE inhibition to limit their pro-arrhythmic effects.

Source: Cardiovascular Research - March 18, 2016 Category: Cardiology Authors: Bobin, P., Varin, A., Lefebvre, F., Fischmeister, R., Vandecasteele, G., Leroy, J. Tags: Ion Channels and Arrhythmias Source Type: research