Cardiac hypertrophy is exacerbated in aged mice lacking the osteoprotegerin gene
Conclusion
These results suggest that OPG plays a role in preserving myocardial structure and function with ageing through a reduction in apoptosis and preservation of the matrix structure. In addition, this appears to be independent of effects on the vasculature.
Source: Cardiovascular Research - Category: Cardiology Authors: Hao, Y., Tsuruda, T., Sekita-Hatakeyama, Y., Kurogi, S., Kubo, K., Sakamoto, S., Nakamura, M., Udagawa, N., Sekimoto, T., Hatakeyama, K., Chosa, E., Asada, Y., Kitamura, K. Tags: Cardiac biology and remodelling Source Type: research