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Did You Know Sperm Can Be Developed in a Lab? It's Possible

In a development that may someday help men facing infertility, Chinese scientists have just announced they were able to create sperm in a lab petri dish using embryonic stem cells from mice. The sperm was used to fertilize mouse eggs using in vitro fertilization (IVF), creating healthy babies that went on to have their own offspring. That's promising. Embryonic stem cells can actually develop into any type of cell in the body and have previously been used to create sperm. However, in the past, transforming such cells into sperm required the cells to be transplanted into the testicles of mice. The new technique represents an advance as the sperm was able to develop in a lab dish containing testicle cells. According to study results in the journal Cell Stem Cell, mouse sperm was used to fertilize mouse eggs and of 379 eggs injected, nine babies resulted. After 15 months, all mice appear healthy, and they're having their own offspring. While the sperm developed in the lab is a primitive type, not fully mature, known as spermatids, they still contained their full genetic component and were sufficient to fertilize eggs. Spermatids have been used to create healthy human babies in Japan, while some countries have outlawed the procedure. A number of scientists interviewed about the study results expressed excitement for how the work -- making sperm outside the body -- could aid research into basic sperm development and eventually help infertile men. Some Japanese research...
Source: Science - The Huffington Post - Category: Science Source Type: news

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Fanconi anemia (FA) is a relatively rare genetic condition with primary sequelae of bone marrow failure, hematologic malignancies, and squamous cell cancers (SCC) of head/neck, breast, and anogenital tract. Many patients require hematopoietic stem cell transplant (bone marrow transplant, BMT) to treat marrow dysfunction, but risk of future malignancies remains. Female patients are at risk of reproductive complications, including infertility related to primary ovarian insufficiency (POI) and gynecologic cancers.
Source: Journal of Pediatric and Adolescent Gynecology - Category: OBGYN Authors: Source Type: research
Fight Aging! provides a weekly digest of news and commentary for thousands of subscribers interested in the latest longevity science: progress towards the medical control of aging in order to prevent age-related frailty, suffering, and disease, as well as improvements in the present understanding of what works and what doesn't work when it comes to extending healthy life. Expect to see summaries of recent advances in medical research, news from the scientific community, advocacy and fundraising initiatives to help speed work on the repair and reversal of aging, links to online resources, and much more. This content is...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Abstract Infertile couples including cancer survivors stand to benefit from gametes differentiated from embryonic or induced pluripotent stem (ES/iPS) cells. It remains challenging to convert human ES/iPS cells into primordial germ-like cells (PGCLCs) en route to obtaining gametes. Considerable success was achieved in 2016 to obtain fertile offspring starting with mouse ES/iPS cells, however the specification of human ES/iPS cells into PGCLCs in vitro is still not achieved. Human ES cells will not yield patient-specific gametes unless and until hES cells are derived by somatic cell nuclear transfer (therapeutic cl...
Source: Reproductive Biology - Category: Reproduction Medicine Authors: Tags: Reprod Biol Endocrinol Source Type: research
This study shows that lifespan-extending conditions can slow molecular changes associated with an epigenetic clock in mice livers. Diverse interventions that extend mouse lifespan suppress shared age-associated epigenetic changes at critical gene regulatory regions Age-associated epigenetic changes are implicated in aging. Notably, age-associated DNA methylation changes comprise a so-called aging "clock", a robust biomarker of aging. However, while genetic, dietary and drug interventions can extend lifespan, their impact on the epigenome is uncharacterised. To fill this knowledge gap, we defined...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
STUDY QUESTION Is there an association between the need for medical puberty induction and the diagnosis or treatment received in girls who have undergone cryopreservation of ovarian tissue for fertility preservation? SUMMARY ANSWER There was a clear association between the intensity of treatment received and requirement for medical puberty induction but no association with the diagnosis. WHAT IS KNOWN ALREADY Although it cannot be predicted which girls will become infertile or develop premature ovarian insufficiency (POI) following intensive chemotherapy or irradiation, patients who are at high risk of POI should be offe...
Source: Human Reproduction - Category: Reproduction Medicine Authors: Tags: Puberty, ageing and HRT Source Type: research
Summary Improved treatments have led to an increased survival rate in cancer patients. However, in pre‐pubertal boys, these gonadotoxic treatments can result in the depletion of the spermatogonial stem cell (SSC) pool causing lifelong infertility. SSC transplantation has been proposed as a promising technique to preserve the fertility of these patients. In mice, this technique has resulted in live‐born offspring, but the efficiency of colonization remained low. This could be because of a deficient microenvironment, leading to apoptosis of the transplanted SSCs. Interestingly, mesenchymal stem cells (MSCs), being multip...
Source: Andrology - Category: Urology & Nephrology Authors: Tags: Review Article Source Type: research
In this article, one of the scientists involved in our rejuvenation research community outlines a very reasonable view on cryonics and cryopreservation. Cryonics is the low-temperature preservation of at least the brain following death, done these days with the use of cryoprotectants and vitrifiction to minimize ice crystal formation. It offers an unknown chance at a future restoration to life: technology marches onwards year after year, and for so long as the structures that encode the data of the mind are preserved, there is the possibility of living again in a future age that has mastered the technologies needed for res...
Source: Fight Aging! - Category: Research Authors: Tags: Daily News Source Type: blogs
In this study, hSSCs were isolated from testis biopsies of the patients with maturation arrest and proliferated in DMEM in the presence of LIF and bFGF for 5 weeks. The various types of human spermatogonia were identified in culture system and compared with testis tissue using morphological criteria at the ultrastructural level. The results showed that although many various types of spermatogonia were identified, but no remarkable difference was observed between spermatogonial cells in culture system and testis tissue. Electron and light microscopic studies of hSSC colonies did not show differentiated SSCs in the culture s...
Source: Andrologia - Category: Urology & Nephrology Authors: Tags: Original Article Source Type: research
te; A Abstract Prognosis of patients with acquired aplastic anemia (AA) treated with hematopoietic stem cell transplantation (HSCT) has greatly improved. Nevertheless, long-term morbidity may occur and are responsible for the persistent increased death rates as compared to general population. Most late effects evolve during the first 10 years post-transplant; however, some of them may appear later. Patients with AA undergoing a HSCT from a matched sibling donor (MSD) present a lower incidence of non-malignant late complications when compared to patients transplanted for a malignant disease. In case of unrelated HS...
Source: Current Drug Targets - Category: Drugs & Pharmacology Authors: Tags: Curr Drug Targets Source Type: research
We describe here a multidisciplinary approach to establish testicular tissue banking for males at risk of infertility.
Source: Methods - Category: Molecular Biology Source Type: research
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