Mineral and bone disorders: Targeting CYP24A1

Nature Reviews Nephrology 12, 196 (2016). doi:10.1038/nrneph.2016.16 Author: Susan J. Allison Disturbed phosphate homeostasis is a common feature of chronic kidney disease (CKD). High serum levels of FGF-23 are associated with adverse effects on bone metabolism. New findings suggest that inhibition of the vitamin D-inactivating enzyme, CYP24A1, might present a new therapeutic opportunity for the treatment
Source: Nature Reviews Nephrology - Category: Urology & Nephrology Authors: Tags: Research Highlight Source Type: research