Proteinuria: New therapeutic strategy for proteinuria

Nature Reviews Nephrology 12, 196 (2016). doi:10.1038/nrneph.2016.15 Author: Jessica K. Edwards 4-Phenylbutyric acid (PBA) — a molecular chaperone known to modulate endoplasmic reticulum (ER) function — might be a suitable therapeutic to ameliorate the toxic effects of proteinuria, according to new research. Fabiola Terzi and colleagues report that PBA can inhibit ER stress-induced apoptosis and the
Source: Nature Reviews Nephrology - Category: Urology & Nephrology Authors: Tags: Research Highlight Source Type: research