Mucosal Immune Tolerance in Rheumatoid ArthritisMucosal Immune Tolerance in Rheumatoid Arthritis

Does rheumatoid arthritis originate as mucosal inflammation in an extra-articular location? Read why many believe this is the case. Rheumatology
Source: Medscape Orthopaedics Headlines - Category: Orthopaedics Tags: Rheumatology Journal Article Source Type: news

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In this study, amine-functionalized graphene (afG) was conjugated with antibodies [anti-p24 for HIV, anti-cardiac troponin 1 (anti-cTn1) for CVDs, and anti-cyclic citrullinated peptide (anti-CCP) for RA] to detect various biomarkers. The antibodies were covalently conjugated to afG via carbodiimide activation. The bioconjugate (graphene-antibody) was characterized by various biophysical techniques such as UV–Vis, Raman spectroscopy, scanning electron microscopy (SEM), and atomic force microscopy (AFM). The electrochemical performance of the sensor was evaluated with respect to changes in the resistance of the electro...
Source: Biosensors and Bioelectronics - Category: Biotechnology Source Type: research
Publication date: Available online 14 December 2018Source: Pharmacology &TherapeuticsAuthor(s): Asuncion Martinez-Anton, Delphine Gras, Arnaud Bourdin, Patrice Dubreuil, Pascal ChanezAbstractKIT is a receptor tyrosine kinase that after binding to its ligand stem cell factor activates signaling cascades linked to biological processes such as proliferation, differentiation, migration and cell survival. Based on studies performed on SCF and/or KIT mutant animals that presented anemia, sterility, and/or pigmentation disorders, KIT signaling was mainly considered to be involved in the regulation of hematopoiesis, gametogene...
Source: Pharmacology and Therapeutics - Category: Drugs & Pharmacology Source Type: research
ConclusionIn conclusion, occurrence of VTE in a total of 50,865 RA patients initiating tofacitinib or a TNF inhibitor was infrequent (
Source: Arthritis and Rheumatology - Category: Rheumatology Authors: Tags: Brief Report Source Type: research
FRIDAY, Dec. 14, 2018 -- A nurse-based phone education intervention can promote shared decision making in patients with newly diagnosed rheumatoid arthritis (RA), according to a study published online Dec. 5 in Musculoskeletal Care. Siobhan Farley,...
Source: Drugs.com - Pharma News - Category: Pharmaceuticals Source Type: news
Condition:   Rheumatoid Arthritis Interventions:   Drug: MTX start;   Drug: TNF start Sponsor:   Region Skane Active, not recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Authors: Ha YJ, Han DW, Kim JH, Chung SW, Kang EH, Song YW, Lee YJ Abstract Semaphorin 3A (Sema3A) and semaphorin 4D (Sema4D) are molecules which regulate immune responses as well as bone remodeling process. The aim of this study was to evaluate the serum levels of Sema3A and Sema4D and to investigate their clinical significance in rheumatoid arthritis (RA). The serum levels of Sema3A and Sema4D were measured in 130 patients with RA and 65 sex- and age-matched healthy individuals. Circulating levels of biomarkers of RA-related inflammation and bone turnover such as tumor necrosis factor- (TNF-) α, interleukin...
Source: Disease Markers - Category: Laboratory Medicine Tags: Dis Markers Source Type: research
This report presents details on a 45-year-old male Japanese patient with chronic and refractory anterior uveitis associated with psoriasis vulgaris who was administered certolizumab pegol (CZP), which is an anti-tumor necrosis factor alpha (TNF- α) monoclonal antibody. Although CZP has only been formally approved for rheumatoid arthritis treatment in Japan, a clinical trial allowed us to assess CZP effectiveness in this patient. The grade 3+ anterior chamber inflammation (for both the cells and flare) observed at baseline improved to grade 0 at 3 months post-treatment. Dermatologically, the psoriasis area severity in...
Source: Case Reports in Ophthalmology - Category: Opthalmology Source Type: research
This article reports on three cases presenting with completely different leading symptoms (initially misdiagnosed as seronegative rheumatoid arthritis, spondyloarthritis and adult onset of Still's disease, respectively) that illustrate the rich diversity of WD. The cases were chosen to draw attention to the fact that although WD is mainly associated with the field of gastroenterology and gastrointestinal (GI) involvement is common, it may appear without GI symptoms. In cases of a clinical suspicion of WD, diagnostic efforts should be made to detect the bacterium in the affected organ. The German S2k guidelines on GI i...
Source: Zeitschrift fur Rheumatologie - Category: Rheumatology Authors: Tags: Z Rheumatol Source Type: research
Tocilizumab, an anti-interleukin-6 (IL-6) agent, is indicated as a treatment for several autoimmune or inflammatory diseases, including rheumatoid arthritis and juvenile idiopathic arthritis (JIA). IL-6 plays ...
Source: Pediatric Rheumatology - Category: Rheumatology Authors: Tags: Review Source Type: research
Iatrogenic lymphoproliferative disorders have been described in patients receiving immunosuppressive/immunomodulatory agents outside the transplantation setting. Novel biological agents such as TNF-α blockers and JAK-inhibitors have also proven to be effective in many disorders including rheumatoid arthritis, inflammatory bowel disease (ulcerative colitis and Crohn disease), psoriasis, and others. A significant dilemma exists in those lymphoproliferative disorders associated with immunosuppressants and rheumatologic conditions, that relies on whether the association of the process is with the medication or the underl...
Source: The American Journal of Surgical Pathology - Category: Pathology Tags: Case Report Source Type: research
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