Mucosal Immune Tolerance in Rheumatoid ArthritisMucosal Immune Tolerance in Rheumatoid Arthritis

Does rheumatoid arthritis originate as mucosal inflammation in an extra-articular location? Read why many believe this is the case. Rheumatology
Source: Medscape Orthopaedics Headlines - Category: Orthopaedics Tags: Rheumatology Journal Article Source Type: news

Related Links:

ARTHRITIS symptoms consist of joint stiffness, pain and swelling, among others. Types of the condition include rheumatoid arthritis, psoriatic arthritis and osteoarthritis. You ’re more likely to develop the condition if you’re older, overweight or have a previous injury. This joint exercise can help treat the symptoms.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
This study indicates that frailty and other age-related diseases could be prevented and significantly reduced in older adults. Getting our heart risk factors under control could lead to much healthier old ages. Unfortunately, the current obesity epidemic is moving the older population in the wrong direction, however our study underlines how even small reductions in risk are worthwhile." The study analysed data from more than 421,000 people aged 60-69 in both GP medical records and in the UK Biobank research study. Participants were followed up over ten years. The researchers analysed six factors that could impa...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
This study examined the impact of polymorphisms in NR1I2, adenosine triphosphate–binding cassette (ABC) transporter genes on the pharmacokinetics of CK in healthy Chinese individuals. Methods Forty-two targeted variants in seven genes were genotyped in 54 participants using Sequenom MassARRAY system to investigate their association with major pharmacokinetic parameters of CK and its metabolite 20(S)-protopanaxadiol (PPD). Subsequently, molecular docking was simulated using the AutoDock Vina program. Results ABCC4 rs1751034 TT and rs1189437 TT were associated with increased exposure of CK and decreased exposure of 20(...
Source: Journal of Ginseng Research - Category: Complementary Medicine Source Type: research
ARTHRITIS is a musculoskeletal condition, with symptoms including joint pain, stiffness and swelling. There are several different types, such as rheumatoid arthritis and osteoarthritis. These simple techniques can help sufferers start gardening again for the summer.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
ARTHRITIS is a musculoskeletal condition, with symptoms including joint pain, stiffness and swelling. There are several different types, such as rheumatoid arthritis and osteoarthritis. These simple techniques can help sufferers start gardening again for the summer.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
Vitamin D is a crucial nutrient for bone health. Some studies suggest a link between vitamin D deficiency and joint or muscle pain, including rheumatoid arthritis. In this article, we look at what the research says, how a person can get their daily dose of vitamin D, and other vitamins that could help joint pain.
Source: Health News from Medical News Today - Category: Consumer Health News Tags: Nutrition / Diet Source Type: news
This study was performed to examine whether the AF4/FMR2 family, member 1 (AFF1) rs340630 polymorphism is involved in the genetic background of rheumatoid arthritis (RA) in a Chinese population. Two different study groups of RA patients and controls (328 RA patients and 449 healthy controls in the first study group; 232 RA patients and 313 controls in the second study group) were included in our study. Overall, there was no significant difference in either genotype (P=0.71 and 0.64 in the first and second study group, respectively) nor allele (in the first study group: A vs G, P=0.65, OR=1.05, 95%CI=0.85-1.29; in the secon...
Source: Braz J Med Biol Res - Category: Research Authors: Tags: Braz J Med Biol Res Source Type: research
AbstractSomatostatin and its analogues are known to have modulatory effects on immune response and their anti-proliferative, anti-angiogenic, and analgesic properties make them attractive candidates for a therapeutic use in immune-mediated diseases, such as rheumatoid arthritis. Here, we demonstrate the ability of the somatostatin analogue octreotide to inhibit interleukin-15 and to increase interleukin-10 production by rheumatoid arthritis fibroblast-like synovial cells maintained in a chronic inflammatory state. We also prove that the inhibitory effect of octreotide on interleukin-15 and tumor necrosis factor- α pr...
Source: Inflammation - Category: Allergy & Immunology Source Type: research
Conclusions In all, HRQoL reported by patients is good and has remained unchanged after approximately 6 years of study. The stability of HRQoL is probably partly attributable to treatment.
Source: Reumatologia Clinica - Category: Rheumatology Source Type: research
We reported that a unique PD-1+ MP CD4+ T cell population is increased with age, now termed senescence-associated (SA-) T cells. The SA-T cells show characteristic signs and features of cellular senescence and emerge as follicular T cells in spontaneous germinal centers (GCs) that occur in aged mice. Spontaneous development of GCs is a hallmark of systemic autoimmune diseases, and among a number of changes in immune function with age is an increasing risk for autoimmunity. Link: https://www.ncbi.nlm.nih.gov/books/NBK500331/
Source: Fight Aging! - Category: Research Authors: Tags: Daily News Source Type: blogs
More News: Arthritis | Orthopaedics | Rheumatoid Arthritis | Rheumatology