The Healing Power Of Poop May Surprise You
SAN DIEGO -- Last week at the inaugural Near Future Summit, a leadership conference of forward-thinking professionals, tech entrepreneur Peter Diamandis asked members of the audience to raise their hands if they'd been born vaginally. He then asked them to keep their hands raised if they had also been breastfed and if, in more recent years, they'd avoided antibiotics, Z-Paks and major surgery. In the end, just a few dozen people in the audience of 250 or so still had their hands up. This wasn't just an exercise in TMI: Diamandis was hoping to assess the microbiome status of his listeners. All of the aforementioned qualities suggest that a person's gut bacteria are healthy and undisturbed. Soon after Diamandis' straw poll, the medical philanthropist Lee Stein walked around handing out feces collection kits to the people who might be in possession of the perfect poop. It's unknown how many people at the summit chose to contribute data, so to speak. But any feces that were collected will become part of an in-depth analysis of how gut bacteria can have an effect on the entire body. The person leading this project is Rob Knight, a lanky New Zealander. At 6’3 and about 200 pounds, he looks like a man who's never had a problem with his weight. But in fact, Knight was obese for most of his life. Until 2008, he weighed about 60 pounds more than he does now. If you think Knight lost the weight through hard work, diet and exercise, you’d be wrong. All h...
Publication date: Available online 19 November 2018Source: Brain, Behavior, and ImmunityAuthor(s): Sarah A. Woller, Cody Ocheltree, Stephanie Y. Wong, Anthony Bui, Yuya Fujita, Gilson Gonçalves dos Santos, Tony L. Yaksh, Maripat CorrAbstractIn rheumatoid arthritis, joint pain can persist despite resolution of swelling. Similarly, in the murine K/BxN serum transfer model, a persistent tactile allodynia is observed after the resolution of joint inflammation (post-inflammatory pain) in male mice. Here, we found female wild type (WT) mice show inflammatory, but reduced post-inflammatory tactile allodynia. The transition...
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Hongye Liu, Lei Ding, Huifeng Zhang, David Mellor, Haiyan Wu, Dongmei Zhao, Chuangxin Wu, Zhiguang Lin, Jiaojian Yuan, Daihui Peng
Ling Li, Min Li, Jianping Lu, Xiaohu Ge, Weiguo Xie, Zichen Wang, Xiaoling Li, Chao Li, Xiaoyan Wang, Yan Han, Yifei Wang, Liyan Zhong, Wei Xiang, Xiaodong Huang, Haijia Chen, Paul Yao
Anja Schaich, Laura Heikaus, Nele Assmann, Sandra K öhne, Kamila Jauch-Chara, Michael Hüppe, Adrian Wells, Ulrich Schweiger, Jan Philipp Klein, Eva Fassbinder
Abstract Parental environmental effects-or transgenerational plasticity-can influence an individual's phenotype or fitness yet remain underexplored in the context of global change. Using the perennial self-pollinating plant Boechera stricta, we explored the effects of climate change on transgenerational and within-generation plasticity in dormancy, germination, growth, and survival. We first conducted a snow removal experiment in the field, in which we transplanted 16 families of known origin into three common gardens at different elevations and exposed half of the siblings to contemporary snow dynamics and half t...
Conclusion: This study concludes that the presence of IRW or IQW can mitigate DSS-induced oxidative stress by improving the activities of antioxidant enzymes, increasing intestinal microbial diversity and enhancing the abundance of gut microbiota, which may help maintain the homeostasis of host health and microenvironment in a DSS-induced mouse model, thus providing a potential further treatment for IBD patients.Cell Physiol Biochem 2018;51:441 –451
Conclusion: These results suggest a potentially important new mechanism that regulates glucose transport in podocytes and that could be injurious during diabetes.Cell Physiol Biochem 2018;51:393 –410
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