The Healing Power Of Poop May Surprise You
SAN DIEGO -- Last week at the inaugural Near Future Summit, a leadership conference of forward-thinking professionals, tech entrepreneur Peter Diamandis asked members of the audience to raise their hands if they'd been born vaginally. He then asked them to keep their hands raised if they had also been breastfed and if, in more recent years, they'd avoided antibiotics, Z-Paks and major surgery. In the end, just a few dozen people in the audience of 250 or so still had their hands up. This wasn't just an exercise in TMI: Diamandis was hoping to assess the microbiome status of his listeners. All of the aforementioned qualities suggest that a person's gut bacteria are healthy and undisturbed. Soon after Diamandis' straw poll, the medical philanthropist Lee Stein walked around handing out feces collection kits to the people who might be in possession of the perfect poop. It's unknown how many people at the summit chose to contribute data, so to speak. But any feces that were collected will become part of an in-depth analysis of how gut bacteria can have an effect on the entire body. The person leading this project is Rob Knight, a lanky New Zealander. At 6’3 and about 200 pounds, he looks like a man who's never had a problem with his weight. But in fact, Knight was obese for most of his life. Until 2008, he weighed about 60 pounds more than he does now. If you think Knight lost the weight through hard work, diet and exercise, you’d be wrong. All h...
Abstract AimsTo identify gestational diabetes mellitus exposure‐associated DNA methylation changes and assess whether such changes are also associated with adiposity‐related outcomes. MethodsWe performed an epigenome‐wide association analysis, using Illumina 450k methylation arrays, on whole blood collected, on average, at 10.5 years of age from 81 gestational diabetes‐exposed and 81 unexposed offspring enrolled in the EPOCH (Exploring Perinatal Outcomes in Children) study, and on the cord blood of 31 gestational diabetes‐exposed and 64 unexposed offspring enrolled in our own ‘Healthy Start’ cohort. V...
Adults with obesity should be referred to multicomponent behavioral interventions for weight loss, although evidence reveals modest effects, the task for said.Medscape Medical News
Because of the severe nature of psychiatric illness, electroconvulsive therapy (ECT) is not always an “elective procedure.” The pre-ECT medical evaluation, although important, should not be an impediment to timely ECT. We argue that an arbitrary regulation requiring new assessments every 30 days may be unduly burdensome and unnecessary. The small medical risk of treatment should be weighed against the potential psychiatric risk (including suicide) of delayed treatment.
Conclusions There was substantial heterogeneity in the use of ECT between participating centers, indicating that the Network is representative of modern ECT practice. The Clinical Alliance and Research in ECT Network may therefore offer the opportunity to improve service delivery and facilitate the investigation of unresolved research questions pertaining to modern ECT practice.
Conclusions Defense Automated Neurobehavioral Assessment is an electronic, mobile, repeatable, sensitive, and valid method of measuring cognition over time in depressed patients undergoing electroconvulsive therapy treatment. Automation of the DANA allows for more frequent cognitive testing in a busy clinical setting and enhances cognitive assessment sensitivity with a timed component to each test.
Conclusions The 10-Item Orientation Questionnaire when administered at 30 minutes after ECT is sensitive for detecting patients with slow recovery of orientation after ECT. Use of this instrument therefore has potential for improving routine patient monitoring in clinical practice and identifying patients at increased risk of retrograde memory adverse effects following treatment.
Conclusions The majority of participants who had received ECT before age 18 years reported mild or absence of depression and anxiety on self-rated follow-up measures after treatment with ECT. Most notably, the majority reported absence of suicidality and adequate academic performance. A number of respondents, however, continued to endorse global impairment, which may be a reflection of their baseline severe illness, which had warranted treatment with ECT.
Conclusions Based on the literature and our own clinical experience, ECT seems to be a safe option for the treatment of core psychopathology with comorbid MG as long as appropriate precautions are in place, particularly when choosing an anesthetic approach.
We report the successful ECT treatment of depression in an older man who had developed a subarachnoid hemorrhage after a suicide attempt by ingestion of antifreeze.
Conclusions Anodal tDCS to the rTPJ may represent an effective treatment for improving social functioning in ASD, with a larger clinical trial needed to validate this effect.
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