Linkage and related analyses of Barrett's esophagus and its associated adenocarcinomas

ConclusionOur linkage study of BE/EAC pedigrees identified linkage regions on chromosomes 2, 4, 12, and 15, with some reported associations located within our linkage peaks. Our linkage results can help prioritize association tests to delineate the genetic determinants underlying susceptibility to BE and EAC.

We identified linkage regions on chromosomes 2q31, 12q23, and 15q26. Some of our linkage regions are consistent with reported genomic associations to BE and EAC. Our linkage results can help prioritize association tests to delineate the genetic determinants underlying susceptibility to Barrett's esophagus and esophageal adenocarcinomas, and help focus the search for causal genes.

Source: Molecular Genetics & Genomic Medicine - January 1, 2016 Category: Genetics & Stem Cells Authors: Xiangqing Sun, Robert Elston, Gary W. Falk, William M. Grady, Ashley Faulx, Sumeet K. Mittal, Marcia I. Canto, Nicholas J. Shaheen, Jean S. Wang, Prasad G. Iyer, Julian A. Abrams, Joseph E. Willis, Kishore Guda, Sanford Markowitz, Jill S. Barnholtz‐Sloa Tags: Original Article Source Type: research