Is caffeine intake a risk factor leading to infertility? A protocol of an epidemiological systematic review of controlled clinical studies
Abstract
Background
Previous studies showed that high dose of caffeine intake may induce some specific human reproductive system diseases, even lead to infertility.
Objectives
In consideration of the high consumption of caffeine according to the latest population-based survey, this review is aimed to systematically review the evidence from all controlled clinical studies of caffeine intake for infertility.
Designs
Relevant randomized/quasi-randomized controlled trials, non-randomized clinical studies, cohort studies, and case-control studies will be included in this review. Participants will be either those without a history of infertility who are willing to have a baby (for prospective studies) or infertile patients with confirmed diagnosis (for retrospective studies). Caffeine or caffeine-containing beverage will be observed as the exposure factor. The key outcome will be the diagnosis of infertility in participants. All relevant published/unpublished or ongoing studies will be searched from seven databases and four online systems until December 2015. Two authors will screen the literatures and extract the data independently. Methodological quality of the included studies will be assessed by two authors according to either Risk of Bias Asses...
Source: Systematic Reviews - Category: Global & Universal Source Type: research
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