Xeljanz XR (tofacitinib citrate) Modified Release Tablets For the Treatment of Rheumatoid Arthritis

Xeljanz XR (tofacitinib citrate) is an 11mg once-daily oral JAK inhibitor developed by Pfizer for the treatment of moderate to severe Rheumatoid Arthritis (RA).
Source: Drug Development Technology - Category: Pharmaceuticals Source Type: news

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ARTHRITIS is a musculoskeletal condition, with symptoms including joint pain, stiffness and swelling. There are several different types, such as rheumatoid arthritis and osteoarthritis. These simple techniques can help sufferers start gardening again for the summer.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
ARTHRITIS is a musculoskeletal condition, with symptoms including joint pain, stiffness and swelling. There are several different types, such as rheumatoid arthritis and osteoarthritis. These simple techniques can help sufferers start gardening again for the summer.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
Vitamin D is a crucial nutrient for bone health. Some studies suggest a link between vitamin D deficiency and joint or muscle pain, including rheumatoid arthritis. In this article, we look at what the research says, how a person can get their daily dose of vitamin D, and other vitamins that could help joint pain.
Source: Health News from Medical News Today - Category: Consumer Health News Tags: Nutrition / Diet Source Type: news
This study was performed to examine whether the AF4/FMR2 family, member 1 (AFF1) rs340630 polymorphism is involved in the genetic background of rheumatoid arthritis (RA) in a Chinese population. Two different study groups of RA patients and controls (328 RA patients and 449 healthy controls in the first study group; 232 RA patients and 313 controls in the second study group) were included in our study. Overall, there was no significant difference in either genotype (P=0.71 and 0.64 in the first and second study group, respectively) nor allele (in the first study group: A vs G, P=0.65, OR=1.05, 95%CI=0.85-1.29; in the secon...
Source: Braz J Med Biol Res - Category: Research Authors: Tags: Braz J Med Biol Res Source Type: research
AbstractSomatostatin and its analogues are known to have modulatory effects on immune response and their anti-proliferative, anti-angiogenic, and analgesic properties make them attractive candidates for a therapeutic use in immune-mediated diseases, such as rheumatoid arthritis. Here, we demonstrate the ability of the somatostatin analogue octreotide to inhibit interleukin-15 and to increase interleukin-10 production by rheumatoid arthritis fibroblast-like synovial cells maintained in a chronic inflammatory state. We also prove that the inhibitory effect of octreotide on interleukin-15 and tumor necrosis factor- α pr...
Source: Inflammation - Category: Allergy & Immunology Source Type: research
Conclusions In all, HRQoL reported by patients is good and has remained unchanged after approximately 6 years of study. The stability of HRQoL is probably partly attributable to treatment.
Source: Reumatologia Clinica - Category: Rheumatology Source Type: research
We reported that a unique PD-1+ MP CD4+ T cell population is increased with age, now termed senescence-associated (SA-) T cells. The SA-T cells show characteristic signs and features of cellular senescence and emerge as follicular T cells in spontaneous germinal centers (GCs) that occur in aged mice. Spontaneous development of GCs is a hallmark of systemic autoimmune diseases, and among a number of changes in immune function with age is an increasing risk for autoimmunity. Link: https://www.ncbi.nlm.nih.gov/books/NBK500331/
Source: Fight Aging! - Category: Research Authors: Tags: Daily News Source Type: blogs
CONCLUSION: FA-PSA-CC micelles demonstrated significant advantages in terms of the suppression of inflammation and the treatment of inflammatory arthritis. These reliable and stable micelles possess a high potential to be transferred for clinical use. PMID: 29790372 [PubMed - in process]
Source: Drug Delivery - Category: Drugs & Pharmacology Tags: Drug Deliv Source Type: research
Publication date: Available online 24 May 2018 Source:Biocatalysis and Agricultural Biotechnology Author(s): S. Srividya, G. Sridevi, B. Santhosh Kumar, T.P. Sastry Allogenous grafts with excellent biocompatibility and immuno-compatibility play a major role in most of the biomedical applications. In this regard, the present study focuses on fabricating a novel bone graft material containing biopolymers and phytochemicals which can replace the use of autogenous graft with high biocompatibility and osteogenecity. Based on this, a bone graft material was synthesized using biphasic calcium phosphate (BCP), casein (CA), hen eg...
Source: Biocatalysis and Agricultural Biotechnology - Category: Biotechnology Source Type: research
Genome-wide association study of response to methotrexate in early rheumatoid arthritis patients, Published online: 25 May 2018; doi:10.1038/s41397-018-0025-5Genome-wide association study of response to methotrexate in early rheumatoid arthritis patients
Source: The Pharmacogenomics Journal - Category: Drugs & Pharmacology Authors: Source Type: research
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